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http://hdl.handle.net/10637/15772Polymorphisms associated with adalimumab and infliximab response in moderate to-severe plaque psoriasis
| Title: | Polymorphisms associated with adalimumab and infliximab response in moderate to-severe plaque psoriasis |
| Authors : | Ovejero Benito, María del Carmen Prieto Pérez, Rocío Llamas Velasco, Mar Muñoz Aceituno, Ester Reolid, Alejandra Saiz Rodríguez, Miriam Belmonte, Carmen Román, Manuel Ochoa Mazarro, Dolores Talegón, María Cabaleiro, Teresa Daudén, Esteban Abad-Santos, Francisco |
| Keywords: | Psoriatic patients; Pharmacogenetics |
| Publisher: | Future Medicine |
| Citation: | Ovejero-Benito MC, Prieto-Pérez R, Llamas-Velasco M, Muñoz-Aceituno E, Reolid A, Saiz-Rodríguez M, Belmonte C, Román M, Ochoa D, Talegón M, Cabaleiro T, Daudén E, Abad-Santos F. Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis. Pharmacogenomics. 2018 Jan;19(1):7-16. doi: 10.2217/pgs-2017-0143 |
| Abstract: | Aims-. This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials and methods-. Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (N=95) and 6 months of treatment (N=90). Significant SNPs for univariate analysis were subjected to multivariate analysis. Results/Conclusions-. Five SNPs were associated with PASI75 at 3 months: rs6661932 (IVL), rs2546890 (IL12B), rs2145623 (NFKBIA), rs9304742 (ZNF816A) and rs645544 (SLC9A8). Furthermore, rs1061624 (TNFR1B) was associated with PASI75 at 6 months. Nevertheless, these biomarkers should be validated in large-scale studies before implementation in clinical practice. |
| Description: | Versión en abierto siguiendo la política de la revista |
| URI: | http://hdl.handle.net/10637/15772 |
| Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| ISSN: | 1744-8042 |
| Issue Date: | 1-Dec-2017 |
| Center : | Universidad San Pablo-CEU |
| Appears in Collections: | Facultad de Farmacia |
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