Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/1084

High-performace liquid chromatographic analysis of dextromethorphan guaifenesin and benzoate in a cough syrup for stability testing.


Thumbnail

See/Open:
 High_Galli&Barbas_J_Chromat_A_2004.pdf
102,18 kB
Adobe PDF
Title: High-performace liquid chromatographic analysis of dextromethorphan guaifenesin and benzoate in a cough syrup for stability testing.
Authors : Galli, Verónica
Barbas Arribas, Coral.
Keywords: AnalysisCough syrupValidationForced degradation
Abstract: A method has been developed for the analysis of a cough syrup containing dextromethorphan, guaifenesin, benzoic acid, saccharin and other components. Forced degradation was also studied to demonstrate that the method could be employed during a stability study of the syrup. Final conditions were phosphate buffer (25 mM, pH 2.8) with triethylamine (TEA)–acetonitrile (75:25, v/v). In such conditions, all the actives, excipients and degradation products were baseline resolved in less than 14 min, and different wavelengths were used for the different analytes and related compounds.
Description: En: Journal of chromatography A. ISSN 0021-9673, 2004. n. 1048 : 207-211 p.
URI: http://hdl.handle.net/10637/1084
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Issue Date: 19-Sep-2004
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia





Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.