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Effect of a high-fat diet on pancreatic insulin release, glucose tolerance and hepatic gluconeogenesis in male rats.
Title: | Effect of a high-fat diet on pancreatic insulin release, glucose tolerance and hepatic gluconeogenesis in male rats. |
Authors : | Blázquez Fernández, Enrique Herrera Castillón, Emilio. Castro, Mario |
Abstract: | Male rats were fed a high-fat diet (B) and compared with age and sex paired controls fed a standard diet (A). After an 18 hr fast, the plasma levels of glucose and insulin were lower in B than in A and the oral glucose tolerance were less in the B group. Insulin release in vitro by the pancreas of the rats on the high-fat diet was lower than in the controls. The formation of glucose-C14 from alanine-C11 (IO-' M) by liver slices was higher and that of lactic acid-C14, pyruvic acid-C14 and C14O2 was lower in B vs A when the animals were fed. After a 48 hr fast the A group shows higher gluconeogenesis than when fed, while B remains at the fed rate, in such a way that the formation of glucose-C14 in A vs B is not different when the animals were fasted. The decreased pancreatic insulin release in B could result in such an activation of hepatic gluconeogenesis, that a further increase with fasting is no longer possible. |
Description: | En: Revista Española de Fisiología, ISSN 0034-9402 1971. N. 27, pp 297-304 |
URI: | http://hdl.handle.net/10637/1031 |
Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
Issue Date: | 19-Sep-1971 |
Center : | Universidad San Pablo-CEU |
Appears in Collections: | Facultad de Farmacia |
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