1. Investigación

Inflammatory cytokines are involved in attention deficit hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder. To quantify the baseline levels of pro- and anti-inflammatory cytokines and their changes after methylphenidate (MPH), a total of 31 prepubertal children with ADHD were recruited and subclassified into only two ADHD presentations—ADHD attention deficit (n = 13) or ADHD combined (n = 18). The children were also screened for oppositional defiant conduct disorder (ODCD) and anxiety disorder. Blood samples were drawn at 09:00 and after 4.63 ± 1.87 months of treatment. Four pro-inflammatory cytokines (interleukin-1beta (IL-1β), IL-5, IL-6, tumor necrosis factor-alpha (TNF-α)) and three anti-inflammatory cytokines (IL-4, IL-10, IL-13) were measured using a Luminex® assay. For statistics, a factorial analysis was performed in Stata 15.1. Overall, there were no statistically significant differences in the interleukin (IL) values induced by treatment. When grouped by presentation, the differences were present almost exclusively in ADHD-AD, usually with a profile opposite to that observed in ADHD-C, and with interactions between comorbid factors, with IL-1β (p = 0.01) and IL-13 (p = 0.006) being the ones reaching the greatest statistical significance. These differences are probably related to the ODCD factor, and they disappear after treatment. In conclusion, the changes observed in cytokine levels in prepubertal children only in the ADHD-AD presentation are probably related to comorbidities (specifically ODCD) and are mitigated after treatment.

Some studies have been conducted in Ethiopia to analyze the predictive factors associated with recovery or mortality in children with acute malnutrition, but no recent studies carried out in Oromia have analyze nutritional recovery status in this children. we studied the factors affecting nutritional recovery for survival in acutely malnourished children Southern Ethiopia. cohort study that included the children admitted to the (blinded for review) hospital (Oromia, Ethiopia) for acute malnutrition from January 2015 to December 2016 (n = 440). Kaplan–Meier tests and log-rank tests were used to describe the survival. Chi-squared tests and Spearman and Mann–Whitney U correlation tests were also employed. The mean survival time was shorter in children with severe versus moderate malnutrition at admission (49 days vs. 101 days; log-rank p = 0.042). The survival time was shorter in children with severe acute malnutrition at the time of admission. Survival time of children with moderate acute malnutrition was shorter in children who came from rural areas compared to urban areas. Severe acute malnutrition was associated with hospital stays, death rates, or transfer to another hospital. Practical implications: the results of this study may improve the care of children with malnutrition.

Aims and Objectives: To determine the effect of immersive virtual reality (VR) on perceived pain and fear in children during vaccination and parental satisfaction with the procedure. Background: Virtual reality can reduce the perception of pain by children but only three studies have analysed its use during vaccination to date; these had small sample sizes and imperfect methodological designs. Design: A randomised controlled clinical trial. Methods: One hundred and sixty participants from the Tres Forques Health Center were randomly assigned to the intervention group (IG) (n = 82) in which distraction with immersive VR was used during the vaccination, while standard distraction techniques were used for the control group (n = 80). The primary outcome was pain (Wong–Baker FACES). Secondary outcomes included (Children's Fear Scale) and parental satisfaction with the vaccination procedure. Chi-squared tests were used for qualitative variables, relationships between quantitative variables were tested with Spearman correlations, and Mann–Whitney U- or Student t-tests were employed to assess the relationship between quantitative and qualitative variables. Results: Compared to the controls, the children in the IG reported significantly less pain and fear, while parental satisfaction was significantly higher. Reported pain and fear did not differ according to the sex of the patient. Child age was not linked to fear but was related to pain: the younger the patient, the greater the pain they described. Conclusions: Immersive VR effectively controlled pain and fear in children during vaccination and increased parent satisfaction with the vaccination process. Patient sex did not influence the level of pain and fear but age did. Relevance to clinical practice: Improving vaccination experiences can reduce perceived pain and fear in children and increase parent satisfaction, thereby enhancing vaccination schedule adherence and improving group immunity. Reporting Method: The CONSORT Statement for non-pharmacological randomised clinical trials were followed.

Chimpanzees help conspecifics achieve their goals in instrumental situations, but neither their immediate motivation nor the evolutionary basis of their motivation is clear. In the current study, we gave chimpanzees the opportunity to instrumentally help a conspecific to obtain food. Following recent studies with human children, we measured their pupil diameter at various points in the process. Like young children, chimpanzees’ pupil diameter decreased soon after they had helped. However, unlike children, chimpanzees’ pupils remained more dilated upon watching a third party provide the needed help instead of them. Our interpretation is that chimpanzees are motivated to help others, and the evolutionary basis is direct or indirect reciprocity, as providing help oneself sets the conditions for a payback. This is in contrast to young children whose goal is to see others being helped—by whomever—presumably because their helping is not based on reciprocity. (PsycInfo Database Record (c) 2021 APA, all rights reserved)