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Comparative utilization of glycerol and alanine as liver gluconeogenic substrates in the fed late pregnant rat.

Título : Comparative utilization of glycerol and alanine as liver gluconeogenic substrates in the fed late pregnant rat.
Autor : Zorzano, Antonio
Herrera Castillón, Emilio.
Resumen : -I. The appearance of plasma [ 14C]glucose in the inferior cava vein after a pulse of 0.2 mmol of [U- 14C]L-alanine or [U-14C]glycerol/200 g body wt given through the portal vein was studied in fed 21 day pregnant rats and virgin controls under pentobarbital anesthesia. In both groups values were much higher when [U- 14C]glycerol was the administered tracer than when [U- 14C]L-alanine, and they were augmented in pregnant versus virgin animals at 1 min when receiving [U- 14C]glycerol and at 2 min when receiving [U- 14C]L-alanine. 2. 20 min after the tracers rats receiving (U- 14C]glycerol showed much higher liver ( 14C]g]ycogen and [ 14C]glyceride glycerol than those receiving [U- 14C]L-alanine. Radioactivity present in liver as [1 4C]glyceride glycerol was greater in pregnant than in virgin rats receiving [U- 14C]glycerol whereas radioactivity corresponding to [ 14C]fatty acids was lower in the former group receiving either tracer. 3. At 20 min after maternal treatments fetuses showed lower plasma [' 4 C]glycerol than [ 14C]alanine values but plasma [ 14C]glucose and liver [ 14C]glycogen values were much greater in fetuses from mothers receiving [U- 14C]glycerol than (U- 14C]L-alanine. 4. Besides showing the higher gluconeogenic efficiency in pregnant than in virgin rats, results indicate that at late gestation glycerol is used as a preferential substrate for both glucose and glyceride glycerol synthesis in liver.
Descripción : En: International Journal of Biochemistry ISSN 0020-711x, 1986. n. 18, pp 583-587
URI : http://hdl.handle.net/10637/986
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-1986
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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