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Insulin-induced up-regulation of lipoprotein lipase messenger ribonucleic acid and activity in mammary gland.

Título : Insulin-induced up-regulation of lipoprotein lipase messenger ribonucleic acid and activity in mammary gland.
Autor : Ramos Álvarez, María del Pilar
Herrera Castillón, Emilio.
Martín Hidalgo, Antonia
Resumen : The effects of insulin on lipoprotein lipase (LPL) messenger RNA (mRNA) were studied in mammary glands from virgin and late-pregnant rats. Virgin and pregnant rats (at 17 days of gestation) were subjected to a continuous infusion (35 ml/day) with 50% glucose for 72 h to produce a prolonged hyperinsulinemic-euglycemic condition. Gestation causes a 4-fold increase in LPL mRNA accompanied by a 3- to 4-fold increase in total LPL activity. Experimental hyperinsulinemia, generated by the 50% glucose infusion, had a similar effect in both pregnant and virgin rats, by enhancing (2- to 3-fold) both their LPL activity and LPL mRNA. Thus, total LPL activity and LPL mRNA significantly correlated with plasma insulin (r 5 0.789, P , 0.001; and r 5 0.772, P , 0.001, respectively). Furthermore, total LPL activity was correlated with LPL mRNA (r 5 0.765, P 5 0.001). In conclusion, the present study shows that insulin participates in the control of LPL expression in mammary glands, revealing its role as a modulator of the enzyme at a mRNA level.
Descripción : En: Endocrinology. 1999. n. 140 : 1089-1093 p. 0013-7227
URI : http://hdl.handle.net/10637/903
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-1999
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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