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Effect of liber disorders on ethanol elimination and alcohol and aldehyde dehydrogenase activities in liver and erythrocytes.


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Title: Effect of liber disorders on ethanol elimination and alcohol and aldehyde dehydrogenase activities in liver and erythrocytes.
Authors : Zorzano, Antonio
Ruíz del Arbol, Luis
Herrera Castillón, Emilio.
Keywords: Alcohol dehydrogenase.Aldehyde dehydrogenase.Cirrhosis.Hepatitis.
Abstract: Our data demonstrate that (a) marked modifications in ADH activity, as found in patients with atypical ADH or in subjects with alcoholic liver disease, are not accompanied by parallel alterations in the kinetics of ethanol disappearance, suggesting that ADH activity per se does not limit ethanol metabolism in viva, (b) hepatic high-Km ALDH activity is decreased in patients with liver disease independent of alcoholism, and therefore decreased ALDH activity cannot be considered as a primary defect in alcoholism but as a consequence of liver damage. and (c) erythrocyte ALOH does not reflect hepatic high-Km ALOH.
Description: En: Clinical science. 1989. n. 76, p. 51-55, 0143-5221
URI: http://hdl.handle.net/10637/799
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Issue Date: 19-Sep-1989
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia





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