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Título : Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic Bacterium / David Rojo ... [et al.].
Autor : Barbas Arribas, Coral.
Materias: Metabolitos.
Fecha de publicación : 16-sep-2014
Resumen : Titania (TiO2)-based nanocomposites subjected to light excitation are remarkably effective in eliciting microbial death. However, the mechanism by which these materials induce microbial death and the effects that they have on microbes are poorly understood. Here, we assess the low dose radical-mediated TiO2 photocatalytic action of such nanocomposites and evaluate the genome/proteome-wide expression profiles of Pseudomonas aeruginosa PAO1 cells after two minutes of intervention. The results indicate that the impact on the gene-wide flux distribution and metabolism is moderate in the analysed time span. Rather, the photocatalytic action triggers the decreased expression of a large array of genes/proteins specific for regulatory, signalling and growth functions in parallel with subsequent selective effects on ion homeostasis, coenzyme-independent respiration and cell wall structure. The present work provides the first solid foundation for the biocidal action of titania and may have an impact on the design of highly active photobiocidal nanomaterials.
Descripción : Artículo en colaboración con : Kubacka A, Suárez Diez M, Bargiela R, Ciordia S, Zapico I, Albar JP, Barbas C, Martins dos Santos VAP, Fernández-García M, Ferrer M.
En: Scientific Reports. ESSN. 2045-2322. v. 4 (2014) 4134, DOI: 10.1038/srep04134
URI : http://hdl.handle.net/10637/7659
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000624692
Aparece en las colecciones: Facultad de Farmacia

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