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dc.creatorKubacka, Anna-
dc.creatorSuárez Diez, María-
dc.creatorRojo Blanco, David-
dc.creatorBargiela, Rafael-
dc.creatorCiordia, Sergio-
dc.creatorZapico, Inés-
dc.creatorAlbar, Juan P.-
dc.creatorBarbas Arribas, Coral.-
dc.creatorMartins dos Santos, Victora A. P.-
dc.creatorFernández-GarcÍa, Marcos-
dc.creatorFerrer, Manuel-
dc.date2014es
dc.date.accessioned2015-09-16T04:00:12Z-
dc.date.available2015-09-16T04:00:12Z-
dc.date.issued2014-09-16-
dc.identifier000000624692es
dc.identifier.urihttp://hdl.handle.net/10637/7659-
dc.descriptionEn: Scientific Reports. ESSN. 2045-2322. v. 4 (2014) 4134, DOI: 10.1038/srep04134es
dc.description.abstractTitania (TiO2)-based nanocomposites subjected to light excitation are remarkably effective in eliciting microbial death. However, the mechanism by which these materials induce microbial death and the effects that they have on microbes are poorly understood. Here, we assess the low dose radical-mediated TiO2 photocatalytic action of such nanocomposites and evaluate the genome/proteome-wide expression profiles of Pseudomonas aeruginosa PAO1 cells after two minutes of intervention. The results indicate that the impact on the gene-wide flux distribution and metabolism is moderate in the analysed time span. Rather, the photocatalytic action triggers the decreased expression of a large array of genes/proteins specific for regulatory, signalling and growth functions in parallel with subsequent selective effects on ion homeostasis, coenzyme-independent respiration and cell wall structure. The present work provides the first solid foundation for the biocidal action of titania and may have an impact on the design of highly active photobiocidal nanomaterials.en-EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.relationFinanciado con cargo a proyectos de I+D nacional con referencia CTQ 2011-23562es
dc.relationFinancial support provided by grants CTQ2010-14872/BQU, PRI-PIBJP-2011-0914 and BIO2011-25012. A.K. thanks the ‘‘Ministerio de Economia y Competitividad’’ MINECO (Spain) for a Ramon y Cajal Fellowship. D.R. received a fellowship from the Spanish Ministry of Economy and Competitiveness (formerly MICINN).en-EN
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectMetabolitos.es
dc.titleUnderstanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic Bacterium.es
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/7659-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/624692/thumb_europeana/624692.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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