Peroxisome proliferator-activated recptor-a expression in rat liver during postnatal development.

Abstract

The expression of the peroxisome proliferator-activated receptor-a (PPARa) as well as of some related genes was studied in rat liver at different stages of development (from 19-day-old fetuses to 1 month-old rats). The level of PPARa mRNA appeared higher in neonates than in fetuses or 1 month-old rats. Whereas the pattern for phosphoenolpyruvate carboxykinase (PEPCK) mRNA level was similar to that of PPARa, the mRNA level of both acyl-CoA oxidase (ACO) and apolipoprotein CIII (apo CIII) showed diverse profiles. Western blotting analysis also revealed an increased level of PPARa protein in liver of suckling rats. Similarities of mRNA PEPCK and PPARa expression indicate a common control mechanism, where both nutritional and hormonal factors may be involved. © 2000 Societe frarn;:aise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS