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Teratogenic effects of diabetes mellitus in the rat : prevention by vitamin E.

Título : Teratogenic effects of diabetes mellitus in the rat : prevention by vitamin E.
Autor : Viana Arribas, Marta
Herrera Castillón, Emilio.
Bonet Serra, Bartolomé
Materias: Diabetes mellitusTeratogenesisFree-radicalsPregnancyvitamin E
Resumen : We wanted to determine whether administration of vitamin E could reduce the production of free radicals which could play a role in the teratogenic effects of diabetes mellitus. Diabetes was induced in Wistar rats by the intravenous administration of streptozotocin. The animals were divided into six groups: one with no supplement (D) and two, supplemented during pregnancy either with oral vitamin E (150 mg/day) (D + E) or with a placebo (safflower oil) (D + 0). Three other groups were kept under the same conditions, but were treated with insulin: D + I, D + I + E and D + I + 0. There were three groups of matched controls: C, C + E and C + 0. All animals were killed on day 11.5 of pregnancy. In C animals the percentages of reabsorptions and malformations were 1.3 and 2 %, respectively, comapred with 23.6, 24.3, 6.2 and 13.2 %, respectively in D and D + I groups. The crown-rump length, number of somites, and protein and DNA content were: higher in C animals than in the diabetic rats, independent of insulin treatment. When vitamin E was administered no changes in these parameters were observed in C and D + I animals; however, in the D mothers it reduced the rate of embryo malformations to 4.6 % and increased the crown-rump length and the number of somites. However, vitamin E did not modify the protein and DNA content and the percentage of reabsorptions. In conclusion, administration of vitamin E to diabetic animals decreases the rate of embryo malformations and increases their size and maturation, supporting a role for free radicals in the teratogenic effects of diabetes.
Descripción : En: Diabetologia. ISSN 0012-186x 1996. n. 39 : 1041-1046 p.
URI : http://hdl.handle.net/10637/755
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-1996
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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