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Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract

Título : Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract
Autor : Acero de Mesa, Nuria
Muñoz Mingarro, Dolores
Navarro, Inmaculada
León-González, Antonio J.
Martín-Cordero, Carmen
Materias: Acanthus mollisAcanthaceaeAnti-inflammatory activityPhytosterols
Editorial : MDPI
Citación : Acero, N.; Muñoz-Mingarro, D.; Navarro, I.; León-González, A.J.; Martín-Cordero, C. Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract. Pharmaceuticals 2023, 16, 159. https://doi.org/10.3390/ph16020159
Resumen : The rhizomes of Acanthus mollis have traditionally been used for the treatment of several ailments involving inflammation. However, to the best of our knowledge, their chemical composition and pharmacological properties have not been studied until now. As a first approach, this study analyses the A. mollis rhizome hexane extract phytochemistry and its anti-inflammatory and antioxidant capacities in HepG2 and RAW 264.7 cell culture assays. Chemical profiling was performed with gas chromatography mass spectrometry without the modification of native molecules. Free phytosterols (such as -sitosterol) account for 70% of detected compounds. The anti-inflammatory capacity of the rhizome extract of A. mollis is mediated by the decrease in the NO production in RAW 264.7 that has previously been stimulated with lipopolysaccharide in a dose-dependent manner. Furthermore, HepG2 pre-treatment with the rhizome extract prevents any damage being caused by oxidative stress, both through ROS scavenge and through the antioxidant cellular enzyme system. In this respect, the extract reduced the activity of glutathione peroxidase and reductase, which were stimulated under oxidative stress conditions. Our results suggest that the extract from the rhizomes of A. mollis may constitute a potential source of natural products with anti-inflammatory activity and could validate the traditional use of A. mollis.
URI : http://hdl.handle.net/10637/15709
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
OpenAccess
ISSN : 1424-8247
Fecha de publicación : 22-ene-2023
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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