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Achieving Regio- and Enantioselectivity of P450-Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure-Guided Directed Evolution
Title: | Achieving Regio- and Enantioselectivity of P450-Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure-Guided Directed Evolution |
Authors : | Agudo Torres, Rubén Roiban, Gheorghe-Doru Reetz, Manfred T. |
Keywords: | Iterative saturation mutagenesis; Oxidative hydroxylation; NADPH |
Publisher: | Wiley |
Citation: | Agudo R, Roiban GD, Reetz MT. Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution. Chembiochem. 2012 Jul 9;13(10):1465-73. doi: 10.1002/cbic.201200244. Epub 2012 Jun 18. PMID: 22711296. |
URI: | http://hdl.handle.net/10637/15682 |
Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
ISSN: | 1439-7633 |
Issue Date: | 9-Jul-2012 |
Center : | Universidad San Pablo-CEU |
Appears in Collections: | Facultad de Farmacia |
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