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Chalcones as Promising Lead Compounds on Cancer Therapy


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Título : Chalcones as Promising Lead Compounds on Cancer Therapy
Autor : León-González, Antonio J.
Acero de Mesa, Nuria
Muñoz Mingarro, Dolores
Navarro Zafra, Inmaculada
Martín-Cordero, Carmen
Materias: ApoptosisCancerChalconeChemopreventionFlavonoidSynthesisTubulin
Editorial : Bentham Science Publishers
Citación : León-González AJ, Acero N, Muñoz-Mingarro D, Navarro I, Martín-Cordero C. Chalcones as Promising Lead Compounds on Cancer Therapy. Curr Med Chem. 2015;22(30):3407-25. doi: 10.2174/0929867322666150729114829
Resumen : Chalcones constitute a group of phenolic compounds that command an increasing interest on cancer research. Natural chalcones are widespread through the plant kingdom. The most abundant and investigated chalcones are isoliquiritigenin, flavokawain and xanthohumol, which are present in the Fabaceae, Piperaceae, Cannabaceae, and Moraceae families. These chalcones have been shown to be promising lead antitumor-chemopreventive drugs by three different activities: antioxidants, cytotoxic and apoptosis inducers. In recent years, SAR (structure-activity relationship) has contributed towards the improvement of anticancer properties of chalcones by substituting aryl rings and introducing heterocyclic moieties. This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer.
Descripción : Versión en acceso abierto siguiendo política de la revista
URI : http://hdl.handle.net/10637/15666
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 1875-533X
Fecha de publicación : 2015
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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