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The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity

Título : The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity
Autor : Muñoz Mingarro, Dolores
Plaza de la Fuente, Adrián
Galán de Mera, Antonio
Vicente Orellana, José Alfredo
Martínez Alcázar, María Paz
Acero de Mesa, Nuria
Materias: AntioxidantsPlant ExtractsReactive Oxygen SpeciesCells
Editorial : Royal Society of Chemistry
Citación : Mingarro, D. Muñoz and Plaza, A. and Galán, A. and Vicente, J. A. and Martínez, M. P. and Acero, N.", The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity, Food Funct., 2015, 6, 8, 2787-2793, The Royal Society of Chemistry, 10.1039/C5FO00645G
Resumen : Plants belonging to the genus Taraxacum are considered a nutritious food, being consumed raw or cooked. Additionally, these plants have long been used in folk medicine due to their choleretic, diuretic, antitumor, antioxidant, antiinflammatory, and hepatoprotective properties. This genus, with its complex taxonomy, includes several species that are difficult to distinguish. Its traditional use must be related not only to T. officinale F.H. Wigg., the most studied species, but also to others. The aim of this work is to compare five different common South European species of Taraxacum (T. obovatum (Willd.) DC., T. marginellum H. Lindb., T. hispanicum H. Lindb., T. lambinonii Soest and T. lacistrum Sahlin), in order to find differences between antioxidant and cytotoxic activities among them. Dissimilarities between species in LC/MS patterns, in in vitro and intracellular antioxidant activity and also in the cytotoxicity assay were found. T. marginellum was the most efficient extract reducing intracellular ROS levels although in in vitro assays, T. obovatum was the best free radical scavenger. A relevant cytotoxic effect was found in T. lacistrum extract over HeLa and HepG2 cell lines.
Descripción : Este artículo es la versión aceptada siguiendo política de la revista
URI : http://hdl.handle.net/10637/15627
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 2042-650X
Fecha de publicación : 25-jun-2015
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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