Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15436

Serum antibodies to phosphatidylcholine in MS


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Title: Serum antibodies to phosphatidylcholine in MS
Authors : Sádaba Argaiz, María Cruz
Rothhammer, Veit
Muñoz Morón, Úrsula
Sebal, Cristina
Escudero Lirola, Esther
Kivisäkk, Pia
García Sánchez, María Isabel
Izquierdo, Guillermo
Hauser, Stephen L.
Baranzini, Sergio E.
Oksenberg, Jorge R.
Álvarez Lafuente, Roberto
Bakshi, Rohit
Weiner, Howard L.
Quintana, Francisco J.
Keywords: Serum immunoglobulin GImmunoglobulin MPhosphatidylcholineLactosylceramideMultiple sclerosis
Publisher: Lippincott, Williams & Wilkins
Citation: Sadaba MC, Rothhammer V, Muñoz Ú, et al. Serum antibodies to phosphatidylcholine in multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation, 7 (4), 2020. http://dx.doi.org/10.1212/NXI.0000000000000765
Abstract: Objective: To evaluate the value of serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies reactive with phosphatidylcholine (PC) and lactosylceramide (LC) as biomarkers in MS. Methods: We developed an ultrasensitive ELISA technique to analyze serum IgG and IgM antibodies to LC and PC, which we used to analyze samples from 362 patients with MS, 10 patients with non-MS myelin diseases (Non-MSMYDs), 11 patients with nonmyelin neurologic diseases (Non-MYNDs), and 80 controls. MS serum samples included clinically isolated syndrome (CIS, n = 17), relapsing-remitting MS (RRMS, n = 62), secondary progressive MS (SPMS, n = 50), primary progressive MS (PPMS, n = 37), and benign MS (BENMS, n = 36). Results: We detected higher levels of serum IgM antibodies to PC (IgM-PC) in MS than control samples; patients with CIS and RRMS showed higher IgM-PC levels than patients with SPMS, PPMS, and BENMS and controls. MS and control samples did not differ in serum levels of IgM antibodies reactive with LC, nor in IgG antibodies reactive with LC or PC. Conclusions: Serum IgM-PC antibodies are elevated in patients with MS, particularly during the CIS and RRMS phases of the disease. Thus, serum IgM-PC is a candidate biomarker for early inflammatory stages of MS. Classification of evidence: This study provides Class III evidence that serum antibodies to PC are elevated in patients with MS. The study is rated Class III because of the case control design and the risk of spectrum bias: antibody levels in patients with MS were compared with healthy controls.
URI: http://hdl.handle.net/10637/15436
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
OpenAccess
ISSN: 2332-7812
Issue Date: 9-Jun-2020
Center : Universidad San Pablo-CEU
Appears in Collections:Medicina





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