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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Medicina.-
dc.contributor.otherGrupo: Respuesta inmune en la Esclerosis Múltiple (RIEM)-
dc.creatorSádaba Argaiz, María Cruz-
dc.creatorRothhammer, Veit-
dc.creatorMuñoz Morón, Úrsula-
dc.creatorSebal, Cristina-
dc.creatorEscudero Lirola, Esther-
dc.creatorKivisäkk, Pia-
dc.creatorGarcía Sánchez, María Isabel-
dc.creatorIzquierdo, Guillermo-
dc.creatorHauser, Stephen L.-
dc.creatorBaranzini, Sergio E.-
dc.creatorOksenberg, Jorge R.-
dc.creatorÁlvarez Lafuente, Roberto-
dc.creatorBakshi, Rohit-
dc.creatorWeiner, Howard L.-
dc.creatorQuintana, Francisco J.-
dc.date.accessioned2024-02-09T17:17:30Z-
dc.date.available2024-02-09T17:17:30Z-
dc.date.issued2020-06-09-
dc.identifier.citationSadaba MC, Rothhammer V, Muñoz Ú, et al. Serum antibodies to phosphatidylcholine in multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation, 7 (4), 2020. http://dx.doi.org/10.1212/NXI.0000000000000765-
dc.identifier.issn2332-7812-
dc.identifier.urihttp://hdl.handle.net/10637/15436-
dc.description.abstractObjective: To evaluate the value of serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies reactive with phosphatidylcholine (PC) and lactosylceramide (LC) as biomarkers in MS. Methods: We developed an ultrasensitive ELISA technique to analyze serum IgG and IgM antibodies to LC and PC, which we used to analyze samples from 362 patients with MS, 10 patients with non-MS myelin diseases (Non-MSMYDs), 11 patients with nonmyelin neurologic diseases (Non-MYNDs), and 80 controls. MS serum samples included clinically isolated syndrome (CIS, n = 17), relapsing-remitting MS (RRMS, n = 62), secondary progressive MS (SPMS, n = 50), primary progressive MS (PPMS, n = 37), and benign MS (BENMS, n = 36). Results: We detected higher levels of serum IgM antibodies to PC (IgM-PC) in MS than control samples; patients with CIS and RRMS showed higher IgM-PC levels than patients with SPMS, PPMS, and BENMS and controls. MS and control samples did not differ in serum levels of IgM antibodies reactive with LC, nor in IgG antibodies reactive with LC or PC. Conclusions: Serum IgM-PC antibodies are elevated in patients with MS, particularly during the CIS and RRMS phases of the disease. Thus, serum IgM-PC is a candidate biomarker for early inflammatory stages of MS. Classification of evidence: This study provides Class III evidence that serum antibodies to PC are elevated in patients with MS. The study is rated Class III because of the case control design and the risk of spectrum bias: antibody levels in patients with MS were compared with healthy controls.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherLippincott, Williams & Wilkins-
dc.relation.ispartofNeurology, Neuroimmunology and Neuroinflammation-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.rightsOpenAccess-
dc.subjectSerum immunoglobulin Gen_EN
dc.subjectImmunoglobulin Men_EN
dc.subjectPhosphatidylcholineen_EN
dc.subjectLactosylceramideen_EN
dc.subjectMultiple sclerosisen_EN
dc.titleSerum antibodies to phosphatidylcholine in MSen_EN
dc.typeArtículoes_ES
dc.identifier.doi10.1212/NXI.0000000000000765-
dc.relation.projectIDNS087867, ES02530, AI126880, and AI093903 from the NIH-
dc.relation.projectIDRSG-14-198-01- LIB from the American Cancer Society to F.J.Q.-
dc.relation.projectIDPCON11/2016 from Banco Santander to M.C.S.-
dc.relation.projectIDUSP-BS-PPC16/2012 and MEMERG-1 from Instituto de Medicina Molecular Aplicada, Universidad San Pablo-CEU, and PI14/01620 from Banco Santander to U.M. V.R.-
dc.relation.projectIDNMSS grant RR 2005-A-13 (RG-1510-06785)-
dc.centroUniversidad San Pablo-CEU-
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