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Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: histological assessment


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Título : Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: histological assessment
Autor : Torres Torrillas, Marta
Damiá Giménez, Elena
Romero Martínez, Ayla del
Peláez Gorrea, Pau
Miguel Pastor, Laura
Chicharro Alcántara, Deborah
Carrillo Poveda, José María.
Rubio Zaragoza, Mónica.
Sopena Juncosa, Joaquín Jesús.
Materias: TerapiaTherapyPlasma sanguíneoBlood plasmaFactores de crecimientoGrowth factorsOsteoartritisOsteoarthritisCartílagosCartilageHistología veterinariaVeterinary histology
Editorial : Frontiers Media
Citación : Torres-Torrillas, M., Damia, E., Del Romero, A., Pelaez, P., Miguel-Pastor, L., Chicharro, D., Carrillo, J.M., Rubio, M. & Sopena, J.J. (2023). Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: histological assessment. Frontiers in Veterinary Science, vol. 10, art. 1131666 (23 mar.). DOI: https://doi.org/10.3389/fvets.2023.1131666
Resumen : Background: Intra-articular (IA) combined with intra-osseous (IO) infiltration of plasma rich in growth factors (PRGF) have been proposed as an alternative approach to treat patients with severe osteoarthritis (OA) and subchondral bone damage. The aim of the study is to evaluate the efficacy of IO injections of PRGF to treat acute full depth chondral lesion in a rabbit model by using two histological validated scales (OARSI and ICRS II). Methodology: A total of 40 rabbits were included in the study. A full depth chondral defect was created in the medial femoral condyle and then animals were divided into 2 groups depending on the IO treatment injected on surgery day: control group (IA injection of PRGF and IO injection of saline) and treatment group (IA combined with IO injection of PRGF). Animals were euthanized 56 and 84 days after surgery and the condyles were processed for posterior histological evaluation. Results: Better scores were obtained in treatment group in both scoring systems at 56- and 84-days follow-up than in control group. Additionally, longer-term histological benefits have been obtained in the treatment group. Conclusions: The results suggests that IO infiltration of PRGF enhances cartilage and subchondral bone healing more than the IA-only PRGF infiltration and provides longer-lasting beneficial effects.
URI : http://hdl.handle.net/10637/15264
Derechos: Open Access
http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2297-1769 (Electrónico)
Fecha de publicación : 29-mar-2023
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal





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