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Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers


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Título : Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers
Autor : Río Sancho, Sergio del
Serna Jiménez, César Eulogio
Calatayud Pascual, María Aracely
Balaguer Fernández, Cristina
Femenía Font, Andrés
Castillo García, Encarnación
Merino, Virginia
López Castellano, Alicia Cristina
Materias: FarmacologíaPharmacologyTratamiento médicoMedical treatmentMedicamentoDrugsEnfermedad de la pielSkin diseases
Editorial : Georg Thieme
Citación : Rio Sancho, S. del, Serna Jiménez, C.E., Calatayud Pascual, M.A., Balaguer Fernández, C., Femenía Font, A., Castillo García, E., Merino, V. & López Castellano, A. (2013). Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers. Planta Medica, vol. 79, i. 2 (jan.), pp. 131–136. DOI: https://doi.org/10.1055/s-0032-1328058
Resumen : Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorption of esculetin, we validated a simple, accurate, precise, and rapid HPLC-UV method. Additionally, the effects of several percutaneous enhancers were studied. Pretreatment of porcine skin was performed with ethanol (control vehicle), decenoic acid, oleic acid, R-(+)-limonene, and laurocapram (Azone®) (5% in ethanol, w/w, respectively). Pretreatment of skin with oleic acid or laurocapram led to statistically significant differences in the transdermal flux of esculetin with respect to controls. Of the two enhancers, laurocapram showed the greatest capacity to enhance the flux of esculetin across pig skin.
Descripción : Este recurso no está disponible en acceso abierto por política de la editorial.
URI : http://hdl.handle.net/10637/15015
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0032-0943
1439-0221 (Electrónico)
Fecha de publicación : ene-2013
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Farmacia





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