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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Farmacia-
dc.creatorFernández Sanjurjo, Manuel-
dc.creatorÚbeda Martín, Natalia-
dc.creatorFernández García, Benjamín-
dc.creatorValle, Miguel del-
dc.creatorRamírez de Molina, Ana-
dc.creatorRamírez de Molina, Ana-
dc.creatorCrespo, María Carmen-
dc.creatorMartín Hernández, Roberto-
dc.creatorCasas Agustench, Patricia-
dc.creatorMartínez Clambor, Pablo-
dc.creatorGonzalo Calvo, David de-
dc.creatorDíez Robles, Sergio-
dc.creatorGarcía González, Ángela-
dc.creatorMontero, Ana-
dc.creatorGonzález González, Felipe-
dc.creatorRabadán, Manuel-
dc.creatorDíaz Martínez, Ángel Enrique-
dc.creatorWhitham, Martin-
dc.creatorIglesias Gutiérrez, Eduardo-
dc.creatorDávalos, Alberto-
dc.date.accessioned2024-01-18T14:45:38Z-
dc.date.available2024-01-18T14:45:38Z-
dc.date.issued2020-07-23-
dc.identifier.citationFernández-Sanjurjo M, Úbeda N, Fernández-García B, et al. Exercise dose affects the circulating microRNA profile in response to acute endurance exercise in male amateur runners. Scand J Med Sci Sports. 2020;30:1896–1907.-
dc.identifier.issn1600-0838-
dc.identifier.urihttp://hdl.handle.net/10637/14970-
dc.description.abstractThe systemic response to exercise is dose-dependent and involves a complex gene expression regulation and cross-talk between tissues. This context ARISES the need for analyzing the influence of exercise dose on the profile of circulating microRNAs (c-miRNAs), as emerging posttranscriptional regulators and intercellular communicators. Thus, we hypothesized that different exercise doses will determine specific c-miRNA signatures that will highlight its potential as exercise dose biomarker. Nine active middle-aged males completed a 10-km race (10K), a half-marathon (HM), and a marathon (M). Blood samples were collected immediately before and after races. Plasma RNA was extracted, and a global screening of 752 microRNAs was analyzed using RT-qPCR. Three different c-miRNA profiles were defined according to the three doses. In 10K, 14 c-miRNAs were found to be differentially expressed between pre- and post-exercise, 13 upregulated and 1 downregulated. Regarding HM, 13 c-miRNAs were found to be differentially modulated, in all the cases upregulated. A total of 28 c-miRNAs were found to be differentially expressed in M, 21 overexpressed and 7 repressed after this race. We had also found 3 common c-miRNAs between 10K and M and 2 common c-miRNAs between 10K and HM. In silico analysis supported a close association between exercise dose c-miRNA profiles and cellular pathways linked to energy metabolism and cell cycle. In conclusion, we have observed that different exercise doses induced specific c-miRNA profiles. So, our results point to c-miRNAs as emerging exercise dose biomarkers and as one of regulatory mechanisms modulating the response to endurance exercise.en_EN
dc.language.isoen-
dc.publisherWiley-
dc.relation.ispartofScandinavian Journal of Medicine and Science in Sports-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.rightsOpenAccess-
dc.subjectCirculating microRNAsen_EN
dc.subjectEndurance exerciseen_EN
dc.subjectExercise biomarkersen_EN
dc.subjectExercise doseen_EN
dc.titleExercise dose affects the circulating microRNA profile in response to acute endurance exercise in male amateur runnersen_EN
dc.typeArtículoen_EN
dc.identifier.doi10.1111/sms.13759-
dc.relation.projectIDMinisterio de Ciencia e Innovación, Grant/ Award Number: AGL2016-78922-R and PID2019-109369RB-I00; Fundación Ramón Areces, Grant/Award Number: CIVP18A3888; Ministerio de Economía,-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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