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Direct measurement of homovanillic, vanillylmandelic and 5-hydroxyindoleacetic acids in urine by capillary electrophoresis.


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Title: Direct measurement of homovanillic, vanillylmandelic and 5-hydroxyindoleacetic acids in urine by capillary electrophoresis.
Authors : García Fernández, Antonia
Heinänen, Maarit
Jiménez, L. M.
Barbas Arribas, Coral.
Keywords: Homovanillic acidVanillylmandelic acidHydroxyindoleacetic acidOrganic acidsCatecholamines
Abstract: Separation conditions in CE, with a neutral coated capillary and reversed polarity, have been optimised to make direct measurement of vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid possible in urine samples without pre-treatment. The method developed has been validated, presenting adequate parameters for linearity, accuracy and precision. Detection limits range from 0.03 to 2.5 mM. Finally the method has been applied to urine samples taken from patients, both adults and children, in hospital. Some of them were also measured by immunoassay and HPLC– electrochemical detection and results have been compared.
Description: En: Journal of chromatography A. 2000. n. 871 : 341-350 p. 0021-9673
URI: http://hdl.handle.net/10637/1004
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Issue Date: 19-Sep-2000
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia





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