Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/754

Differences of muopioid receptors between Lewis and F344 rats.

Title: Differences of muopioid receptors between Lewis and F344 rats.
Authors : Herradón Gil-Gallardo, Gonzalo
Alguacil Merino, Luis Fernando
Morales Goyanes, Lydia
Keywords: LewisFischer 344DAMGOA-opioid receptor
Abstract: F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific A-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of A-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for A-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that A-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. D 2003 Elsevier Science Inc. All rights reserved.
Description: En: Life science. ISSN 0024-3205. v. 73, (2003), p. 1537-1542
URI: http://hdl.handle.net/10637/754
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Issue Date: 2003
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia





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