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http://hdl.handle.net/10637/754Differences of muopioid receptors between Lewis and F344 rats.
| Title: | Differences of muopioid receptors between Lewis and F344 rats. |
| Authors : | Herradón Gil-Gallardo, Gonzalo Alguacil Merino, Luis Fernando Morales Goyanes, Lydia |
| Keywords: | Lewis; Fischer 344; DAMGO; A-opioid receptor |
| Abstract: | F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific A-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of A-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for A-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that A-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. D 2003 Elsevier Science Inc. All rights reserved. |
| Description: | En: Life science. ISSN 0024-3205. v. 73, (2003), p. 1537-1542 |
| URI: | http://hdl.handle.net/10637/754 |
| Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| Issue Date: | 2003 |
| Center : | Universidad San Pablo-CEU |
| Appears in Collections: | Facultad de Farmacia |
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