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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Herradón Gil-Gallardo, Gonzalo | - |
| dc.creator | Alguacil Merino, Luis Fernando | - |
| dc.creator | Morales Goyanes, Lydia | - |
| dc.date | 2003 | - |
| dc.date.accessioned | 2011-09-19T15:40:24Z | - |
| dc.date.available | 2011-09-19T15:40:24Z | - |
| dc.date.issued | 2003 | - |
| dc.identifier | 000000463215 | - |
| dc.identifier.uri | http://hdl.handle.net/10637/754 | - |
| dc.description | En: Life science. ISSN 0024-3205. v. 73, (2003), p. 1537-1542 | - |
| dc.description.abstract | F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific A-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of A-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for A-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that A-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. D 2003 Elsevier Science Inc. All rights reserved. | en-EN |
| dc.format | application/pdf | - |
| dc.language.iso | en | - |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
| dc.subject | Lewis | en-EN |
| dc.subject | Fischer 344 | en-EN |
| dc.subject | DAMGO | en-EN |
| dc.subject | A-opioid receptor | en-EN |
| dc.title | Differences of muopioid receptors between Lewis and F344 rats. | - |
| dc.type | Artículo | - |
| europeana.dataProvider | UNIVERSIDAD SAN PABLO CEU | - |
| europeana.isShownAt | http://hdl.handle.net/10637/754 | - |
| europeana.object | http://repositorioinstitucional.ceu.es/visor/libros/463215/thumb_europeana/463215.jpg | - |
| europeana.provider | Hispana | - |
| europeana.rights | http://creativecommons.org/publicdomain/zero/1.0/ | - |
| europeana.type | TEXT | - |
| dc.centro | Universidad San Pablo-CEU | - |
| Aparece en las colecciones: | Facultad de Farmacia | |
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