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dc.creatorHerradón Gil-Gallardo, Gonzalo-
dc.creatorAlguacil Merino, Luis Fernando-
dc.creatorMorales Goyanes, Lydia-
dc.date2003-
dc.date.accessioned2011-09-19T15:40:24Z-
dc.date.available2011-09-19T15:40:24Z-
dc.date.issued2003-
dc.identifier000000463215-
dc.identifier.urihttp://hdl.handle.net/10637/754-
dc.descriptionEn: Life science. ISSN 0024-3205. v. 73, (2003), p. 1537-1542-
dc.description.abstractF344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific A-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of A-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for A-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that A-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. D 2003 Elsevier Science Inc. All rights reserved.en-EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectLewisen-EN
dc.subjectFischer 344en-EN
dc.subjectDAMGOen-EN
dc.subjectA-opioid receptoren-EN
dc.titleDifferences of muopioid receptors between Lewis and F344 rats.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/754-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/463215/thumb_europeana/463215.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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