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Differences of muopioid receptors between Lewis and F344 rats.

Título : Differences of muopioid receptors between Lewis and F344 rats.
Autor : Herradón Gil-Gallardo, Gonzalo
Alguacil Merino, Luis Fernando
Morales Goyanes, Lydia
Materias: LewisFischer 344DAMGOA-opioid receptor
Resumen : F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific A-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of A-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for A-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that A-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. D 2003 Elsevier Science Inc. All rights reserved.
Descripción : En: Life science. ISSN 0024-3205. v. 73, (2003), p. 1537-1542
URI : http://hdl.handle.net/10637/754
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 2003
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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