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Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis


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Title: Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis
Authors : Gaba, Fariah
Sheth Shah, Chirag Chandrakant
Veses Jiménez, Verónica.
Keywords: Saliva - Análisis.Marcadores tumorales.Cancer cells.Células cancerosas.Saliva - Analysis.Boca - Cáncer.Mouth - Cancer.Tumor markers.
Publisher: John Wiley & Sons.
Citation: Gaba, FI., Sheth, CC. & Veses, V. (2021). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, vol. 50, i. 3 (mar.), pp. 299-307. DOI: https://doi.org/10.1111/jop.12791
Abstract: More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers
Description: Esta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791
URI: http://hdl.handle.net/10637/10614
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN: 0904-2512
1600-0714 (Electrónico)
Issue Date: 19-Mar-2021
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Ciencias Biomédicas





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