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dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherUCH. Departamento de Medicina (Extinguido)-
dc.contributor.otherProducción Científica UCH 2021-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía-
dc.creatorGaba, Fariah-
dc.creatorSheth Shah, Chirag Chandrakant-
dc.creatorVeses Jiménez, Verónica.-
dc.date2021-
dc.date.accessioned2019-09-27T04:00:11Z-
dc.date.available2019-09-27T04:00:11Z-
dc.date.issued2021-03-19-
dc.identifier.citationGaba, FI., Sheth, CC. & Veses, V. (2021). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, vol. 50, i. 3 (mar.), pp. 299-307. DOI: https://doi.org/10.1111/jop.12791-
dc.identifier.issn0904-2512-
dc.identifier.issn1600-0714 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/10614-
dc.descriptionEsta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791-
dc.description.abstractMore than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers-
dc.formatapplication/pdf-
dc.language.isoes-
dc.language.isoen-
dc.publisherJohn Wiley & Sons.-
dc.relation.ispartofJournal of Oral Pathology and Medicine (mar. 2021).-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectSaliva - Análisis.-
dc.subjectMarcadores tumorales.-
dc.subjectCancer cells.-
dc.subjectCélulas cancerosas.-
dc.subjectSaliva - Analysis.-
dc.subjectBoca - Cáncer.-
dc.subjectMouth - Cancer.-
dc.subjectTumor markers.-
dc.titleSalivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1111/jop.12791-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Ciencias Biomédicas




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