Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/9978
Título : Combined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbits / Deborah Chicharro, José M. Carrillo, Mónica Rubio, Ramón Cugat, Belén Cuervo, Silvia Guil, Jerónimo Forteza, Victoria Moreno, José M. Vilar and Joaquín Sopena.
Autor : Chicharro Alcántara, Deborah.
Carrillo Poveda, José María.
Rubio Zaragoza, Mónica.
Cugat Bertomeu, Ramón.
Cuervo Serrato, Belén.
Guil, Silvia.
Forteza, Jerónimo.
Moreno, Victoria.
Vilar, José M.
Sopena Juncosa, Joaquín Jesús.
Materias: Células madre - Uso terapéutico.
Stem cells - Therapeutic use.
Blood plasma - Therapeutic use.
Crecimiento - Factores - Uso terapéutico.
Plasma sanguíneo - Uso terapéutico.
Rabbits - Skin - Wounds and injuries - Treatment.
Cicatrices - Tratamiento.
Scars - Treatment.
Factor de crecimiento epidérmico.
Epidermal growth factor.
Conejos - Piel - Heridas y lesiones - Tratamiento.
Growth factors - Therapeutic use.
Fecha de publicación : 21-sep-2018
Editorial : BioMed Central.
Citación : Chicharro, D., Carrillo, JM., Rubio, M., Cugat, R., Cuervo, B., Guil, S., Forteza, J., Moreno, V., Vilar, JM. and Sopena, J. (2018). Combined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbits. BMC Veterinary Research, vol. 14, art. 288. DOI: https://doi.org/10.1186/s12917-018-1577-y
Resumen : Background: The use of Plasma Rich in Growth Factors (PRGF) and Adipose Derived Mesenchymal Stem Cells (ASCs) are today extensively studied in the field of regenerative medicine. In recent years, human and veterinary medicine prefer to avoid using traumatic techniques and choose low or non-invasive procedures. The objective of this study was to evaluate the efficacy of PRGF, ASCs and the combination of both in wound healing of full-thickness skin defects in rabbits. With this purpose, a total of 144 rabbits were used for this study. The animals were divided in three study groups of 48 rabbits each depending on the administered treatment: PRGF, ASCs, and PGRF+ASCs. Two wounds of 8 mm of diameter and separated from each other by 20 mm were created on the back of each rabbit: the first was treated with saline solution, and the second with the treatment assigned for each group. Macroscopic and microscopic evolution of wounds was assessed at 1, 2, 3, 5, 7 and 10 days post-surgery. With this aim, 8 animals from each treatment group and at each study time were euthanized to collect wounds for histopathological study. Results: Wounds treated with PRGF, ASCs and PRGF+ASCs showed significant higher wound healing and epithelialization rates, more natural aesthetic appearance, significant lower inflammatory response, significant higher collagen deposition and angiogenesis compared with control wounds. The combined treatment PRGF +ASCs showed a significant faster cutaneous wound healing process. Conclusions: The combined treatment PRGF+ASCs showed the best results, suggesting this is the best choice to enhance wound healing and improve aesthetic results in acute wounds.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1577-y
URI : http://hdl.handle.net/10637/9978
ISSN : 1746-6148.
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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