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dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal-
dc.contributor.otherProducción Científica UCH 2018-
dc.creatorChicharro Alcántara, Deborahes
dc.creatorCarrillo Poveda, José María.es
dc.creatorRubio Zaragoza, Mónica.es
dc.creatorCugat Bertomeu, Ramónes
dc.creatorCuervo Serrato, Belénes
dc.creatorGuil, Silviaes
dc.creatorForteza, Jerónimoes
dc.creatorMoreno, Victoriaes
dc.creatorVilar, José M.es
dc.creatorSopena Juncosa, Joaquín Jesús.es
dc.date2018es
dc.date.accessioned2019-02-08T05:01:34Z-
dc.date.available2019-02-08T05:01:34Z-
dc.date.issued2018-09-21-
dc.identifier.citationChicharro, D., Carrillo, JM., Rubio, M., Cugat, R., Cuervo, B., Guil, S., Forteza, J., Moreno, V., Vilar, JM. and Sopena, J. (2018). Combined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbits. BMC Veterinary Research, vol. 14, art. 288. DOI: https://doi.org/10.1186/s12917-018-1577-y-
dc.identifier.issn1746-6148.-
dc.identifier.urihttp://hdl.handle.net/10637/9978-
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1577-yes
dc.description.abstractBackground: The use of Plasma Rich in Growth Factors (PRGF) and Adipose Derived Mesenchymal Stem Cells (ASCs) are today extensively studied in the field of regenerative medicine. In recent years, human and veterinary medicine prefer to avoid using traumatic techniques and choose low or non-invasive procedures. The objective of this study was to evaluate the efficacy of PRGF, ASCs and the combination of both in wound healing of full-thickness skin defects in rabbits. With this purpose, a total of 144 rabbits were used for this study. The animals were divided in three study groups of 48 rabbits each depending on the administered treatment: PRGF, ASCs, and PGRF+ASCs. Two wounds of 8 mm of diameter and separated from each other by 20 mm were created on the back of each rabbit: the first was treated with saline solution, and the second with the treatment assigned for each group. Macroscopic and microscopic evolution of wounds was assessed at 1, 2, 3, 5, 7 and 10 days post-surgery. With this aim, 8 animals from each treatment group and at each study time were euthanized to collect wounds for histopathological study. Results: Wounds treated with PRGF, ASCs and PRGF+ASCs showed significant higher wound healing and epithelialization rates, more natural aesthetic appearance, significant lower inflammatory response, significant higher collagen deposition and angiogenesis compared with control wounds. The combined treatment PRGF +ASCs showed a significant faster cutaneous wound healing process. Conclusions: The combined treatment PRGF+ASCs showed the best results, suggesting this is the best choice to enhance wound healing and improve aesthetic results in acute wounds.-
dc.formatapplication/pdfes
dc.language.isoenes
dc.publisherBioMed Central.-
dc.relationEsta investigación fue financiada por la Fundación García Cugat para la Investigación Biomédica por un proyecto nacional del MINECO (MAT2015-66666-C3-1-R).-
dc.relationFinanciación Nacional.-
dc.relation.ispartofBMC Veterinary Research, vol. 14 (2018).-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.eses
dc.subjectCélulas madre - Uso terapéutico.es
dc.subjectStem cells - Therapeutic use.es
dc.subjectBlood plasma - Therapeutic use.es
dc.subjectCrecimiento - Factores - Uso terapéutico.es
dc.subjectPlasma sanguíneo - Uso terapéutico.es
dc.subjectRabbits - Skin - Wounds and injuries - Treatment.es
dc.subjectCicatrices - Tratamiento.es
dc.subjectScars - Treatment.es
dc.subjectFactor de crecimiento epidérmico.es
dc.subjectEpidermal growth factor.es
dc.subjectConejos - Piel - Heridas y lesiones - Tratamiento.es
dc.subjectGrowth factors - Therapeutic use.es
dc.titleCombined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbitses
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/9978-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/520424/thumb_europeana/520424.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.identifier.doihttps://doi.org/10.1186/s12917-018-1577-y-
dc.relation.projectIDMAT2015-66666-C3-1-R-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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