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dc.creatorBarbas Arribas, Coral.-
dc.creatorGarcía Fernández, Antonia-
dc.creatorSaavedra, Luis-
dc.creatorCastro, Mario-
dc.date2000-
dc.date.accessioned2011-09-19T15:40:12Z-
dc.date.available2011-09-19T15:40:12Z-
dc.date.issued2000-09-19T15:40:12Z-
dc.identifier000000450108-
dc.identifier.urihttp://hdl.handle.net/10637/889-
dc.descriptionEn: Journal of chromatography A. ISSN 0021-9673, 2000. n. 870 : 97-103 p.-
dc.description.abstractThe optimization of a HPLC method for caffeine, 8-chlorotheophylline and diphenhydramine separation with UV detection at 229 nm is described. The conditions studied included: stationary phase, compositions of mobile phases with pH modulators. Optimal conditions were: SymmetryShield RP8 column and acetonitrile–(0.01 M H PO –triethylamine, pH 2.8) 3 4 (22:78, v/v). Validation was performed using standards and a pharmaceutical preparation containing the compounds described above. Results from both standards and samples show suitable validation parameters. The pharmaceutical grade substances were tested by factors that could influence the chemical stability. These reaction mixtures were analyzed to evaluate the capability of the method to separate degradation products. Degradation products did not interfere with the determination of the substances tested by the assay.en-EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectPharmaceutical analysisen-EN
dc.subjectValidationen-EN
dc.subjectStability studiesen-EN
dc.subjectCaffeineen-EN
dc.subjectChlorotheophyllineen-EN
dc.subjectDiphenhydramineen-EN
dc.subjectTheophyllinesen-EN
dc.subjectDimenhydrinateen-EN
dc.titleOptimization and validation of an isocratic HPLC method for caffeine, 8-chlorotheophylline and diphenhydramine determination : stress test for stability evaluation.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/889-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/450108/thumb_europeana/450108.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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