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dc.creatorSevillano Fernández, Julio-
dc.creatorHerrera Castillón, Emilio.-
dc.date1995-
dc.date.accessioned2011-09-19T15:39:34Z-
dc.date.available2011-09-19T15:39:34Z-
dc.date.issued1995-09-19T15:39:34Z-
dc.identifier000000400689-
dc.identifier.urihttp://hdl.handle.net/10637/888-
dc.descriptionEn: American journal of physiology : Endrocrinology and metabolism ISSN 0193-1849 1995. n. 269, pp E858-E863-
dc.description.abstractTo determine whether sustained exaggerated hyperinsulinemia in normoglycemic rats modifies insulin responsiveness during pregnancy, 17-day-pregnant and virgin rats were studied after receiving a continuous intravenous infusion (35 ml/day) of either 50% glucose or bidistilled water (controls) for 72 h. Plasma glucose was unchanged, whereas insulin was highly increased, and the effect was more marked in pregnant than in virgin rats. Insulin responsiveness, estimated under the hyperinsulinemic euglycemic clamp with 0.8 IU insulin· h- 1. kg- 1, was lower in control pregnant than in virgin rats but higher in pregnant than in virgin rats in those that had received the glucose infusion. The tissue glucose utilization metabolic index (GUI) was estimated with 2-deoxyo-ll-3H]glucose in the clamped rats. The GUI was lower in heart, white- and red-fiber skeletal muscle, and adipose tissue in control pregnant rats than in control virgin rats, and, although the glucose infusion decreased that index in both red-fiber muscle and adipose tissue in virgin rats, glucose increased the index in red-fiber muscle in pregnant rats to the level found in virgin controls. Results therefore show that, when unaccompanied by hypoglycemia, sustained exaggerated hyperinsulinemia decreases insulin responsiveness in virgin rats but reverts insulin resistance in late-pregnant rats.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectHyperinsulinemic-euglycemic clamp.en_EN
dc.subjectTissue glucose utilization.en_EN
dc.subjectGestation.en_EN
dc.subjectInsulin responsiveness.en_EN
dc.titleReversion of insulin resistance in the rat during late pregnancy by 72-h glucose infusion.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/888-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/400689/thumb_europeana/400689.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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