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Título : LC determination of impurities in azithromycin tablets / L. Miguel and C. Barbas.
Autor : Miguel, L.
Barbas Arribas, Coral.
Materias: AzithromycinImpuritiesHPLCPharmaceuticals
Fecha de publicación : 19-sep-2003
Resumen : A LC method with UV detection for determining azithromycin impurities in tablets as pharmaceutical form has been developed. It is to be employed in routine and stability tests. A linear gradient elution was employed starting with 47% A and 53% B to reach 28% A and 72% B at 48 min. Mobile phase A was KH2PO4 10 mM (H2O) at pH 7.00. B was a mixture methanol:acetonitrile 1:1 (v/v). UV detection was performed at 210 nm. The chromatographic column was Phenomenex Synergi† MAX-RP 4 mm 250 /460 mm kept at 50 8C. Six impurities were separated and identified and it was possible to quantify five out of the six with reasonable accuracy and precision.
Descripción : En: Journal of pharmaceutical and biomedical analysis. 2003. n. 33 (2) : 211-217 p.
URI : http://hdl.handle.net/10637/782
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000402246
Aparece en las colecciones: Facultad de Farmacia

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