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dc.creatorVallejo, Maríaes
dc.creatorAngulo Díaz-Parreño, Santiagoes
dc.creatorGarcía Fernández, Antoniaes
dc.creatorGarcía, A.-
dc.creatorTuñón, José-
dc.creatorGarcía Martínez, Diana-
dc.creatorMartín Ventura, J. L.-
dc.creatorBlanco Colio, L. M.-
dc.creatorAlmeida, P.-
dc.creatorEgido, Jesús-
dc.creatorBarbas Arribas, Coral.-
dc.date2009es
dc.date.accessioned2013-01-22T05:00:24Z-
dc.date.available2013-01-22T05:00:24Z-
dc.date.issued2009-01-22T05:00:24Z-
dc.identifier000000566728es
dc.identifier.urihttp://hdl.handle.net/10637/4992-
dc.descriptionEn: Analytical and bioanalytical chemistry. 2009, v. 394, n. 6, p. 1517-1524. ISSN 1618-2650es
dc.description.abstractNew biomarkers of cardiovascular disease are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms. One of the approaches used in metabolomics/metabonomics for that purpose is metabolic fingerprinting aiming to profile large numbers of chemically diverse metabolites in an essentially nonselective way. In this study, gas chromatography-mass spectrometry was employed to evaluate the major metabolic changes in low molecular weight plasma metabolites of patients with acute coronary syndrome (n=9) and with stable atherosclerosis (n=10) vs healthy subjects without significant differences in age and sex (n=10). Reproducible differences between cases and controls were obtained with pattern recognition techniques, and metabolites accounting for higher weight in the classification have been identified through their mass spectra. On this basis, it seems inherently plausible that even a simple metabolite profile might be able to offer improved clinical diagnosis and prognosis, but in addition, specific markers are being identified.en-EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.titlePlasma fingerprinting with GC-MS in acute coronary syndrome.es
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/4992-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/566728/thumb_europeana/566728.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
dc.identifier.doiDOI 10.1007/s00216-009-2610-6-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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