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dc.contributor.otherUniversidad San Pablo-CEU. Departamento de Ciencias Farmacéuticas y de la Salud-
dc.creatorGarrosa-Jiménez, Javier-
dc.creatorSánchez Carro, Yolanda-
dc.creatorOvejero Benito, María del Carmen-
dc.creatorDel Sastre, Eric-
dc.creatorGarcía, Antonio G.-
dc.creatorLópez, Manuel G.-
dc.creatorLópez García, Pilar-
dc.creatorCano Abad, María F.-
dc.date.accessioned2024-05-10T17:33:38Z-
dc.date.available2024-05-10T17:33:38Z-
dc.date.issued2021-10-02-
dc.identifier.citationGarrosa-Jiménez J, Sánchez Carro Y, Ovejero-Benito MC, Del Sastre E, García AG, López MG, López-García P, Cano-Abad MF. Intracellular calcium and inflammatory markers, mediated by purinergic stimulation, are differentially regulated in monocytes of patients with major depressive disorder. Neurosci Lett. 2021 Nov 20;765:136275. doi: 10.1016/j.neulet.2021.136275en_EN
dc.identifier.issn0304-3940-
dc.identifier.urihttp://hdl.handle.net/10637/15775-
dc.descriptionDisponible texto en la siguiente URL: https://doi.org/10.1016/j.neulet.2021.136275-
dc.description.abstractThe P2X7 receptor (P2X7R) is a ligand-gated ion channel that is being recognized as a major player in neuropsychiatric disorders such as Major Depressive Disorder (MDD). P2X7R activation is triggered by high extracellular ATP concentrations, leading to channel opening and inducing an increase in cytosolic calcium concentration ([Ca2+]c), that activates the inflammatory pathway. Those receptors are expressed not only in CNS cells but also in peripheral blood cells, where they are activated in response to inflammatory molecules such as bacterial lipopolysaccharide (LPS). LPS induced-tissue damage promotes an elevation of extracellular ATP, triggering the NRLP3-inflammasome assembly and activation that, sequentially, induces caspase-1 cleavage and IL-1β processing and secretion. In this context, we attempt to understand the role of P2X7R in [Ca2+]c homeostasis regulation, inflammasome expression and its pharmacological modulation in MDD. For this purpose, monocytes were isolated from peripheral blood of MDD patients and [Ca2+]c was monitored with the intracellular probe Fura-2. Our results point out to P2X7R as the responsible of the Ca2+ imbalance, as well as TNFα-dependent activation of caspase-1 in MDD patients. In addition, P2X7R blockade with its specific antagonist, JNJ-47965567, reduces the Ca2+ entry upon Bz-ATP exposure. Altogether, our results point that MDD patients have both, Ca2+ homeostasis alteration and an inflammatory status, which promote an independentinflammasome activation of caspase-1. Therefore, we propose the pharmacological modulation of P2X7R as a therapeutic approach against MDD symptoms.en_EN
dc.language.isoen-
dc.publisherElsevier-
dc.relation.ispartofNeuroscience Letters-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectCalcium homeostasisen_EN
dc.subjectInflammationen_EN
dc.titleIntracellular calcium and inflammatory markers, mediated by purinergic stimulation, are differentially regulated in monocytes of patients with major depressive disorderen_EN
dc.typeArtículo-
dc.identifier.doi10.1016/j.neulet.2021.136275-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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