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http://hdl.handle.net/10637/15770Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.other | Universidad San Pablo-CEU. Departamento de Ciencias Farmacéuticas y de la Salud | - |
| dc.contributor.other | Grupo: Parasitología e Inmunología molecular con aplicación biotecnológica, diagnóstica y terapéutica (PARINM) | - |
| dc.creator | Ilie, Adriana | - |
| dc.creator | Lonsdale, Richard | - |
| dc.creator | Agudo Torres, Rubén | - |
| dc.creator | Reetz, Manfred T. | - |
| dc.date.accessioned | 2024-05-10T15:13:35Z | - |
| dc.date.available | 2024-05-10T15:13:35Z | - |
| dc.date.issued | 2015-03-21 | - |
| dc.identifier.citation | A diastereoselective P450-catalyzed epoxidation reaction: anti versus syn reactivity. Ilie A, Lonsdale R, Agudo R, Reetz MT. Tetrahedron Letters 56, 23, pp. 3435 - 3437 (2015). | es_ES |
| dc.identifier.issn | 0040-4039 | - |
| dc.identifier.uri | http://hdl.handle.net/10637/15770 | - |
| dc.description.abstract | The achiral cyclohexene derivative dimethyl cis-1,2,3,6-tetrahydrophthalate has been subjected to oxidation catalyzed by cytochrome P450 monooxygenase P450-BM3, leading to diastereoselective epoxidation rather than oxidative hydroxylation. This reaction occurs with 94% diastereoselectivity in favor of the anti-epoxide, in contrast to m-CPBA which delivers unselectively a 70:30 mixture of anti/syn diastereomers. The experimental results are nicely explained on a molecular level by docking experiments and molecular dynamics computations. | es_ES |
| dc.language.iso | en | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Tetrahedron Letters | - |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
| dc.subject | Biocatalysis | en_EN |
| dc.subject | Oxidation | en_EN |
| dc.subject | Diastereoselectivity | en_EN |
| dc.title | A diastereoselective P450-catalyzed epoxidation reaction: anti versus syn reactivity | en_EN |
| dc.type | Artículo | - |
| dc.identifier.doi | 10.1016/j.tetlet.2015.03.076 | - |
| dc.centro | Universidad San Pablo-CEU | - |
| Aparece en las colecciones: | Facultad de Farmacia | |
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