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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/15722
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dc.contributor.otherUniversidad San Pablo-CEU. Departamento de Ciencias Farmacéuticas y de la Salud-
dc.contributor.otherGrupo: Parasitología e Inmunología molecular con aplicación biotecnológica, diagnóstica y terapéutica (PARINM)-
dc.creatorRoiban, Gheorghe-Doru-
dc.creatorAgudo Torres, Rubén-
dc.creatorReetz, Manfred T.-
dc.date.accessioned2024-04-10T15:26:46Z-
dc.date.available2024-04-10T15:26:46Z-
dc.date.issued2013-05-06-
dc.identifier.citationGheorghe-Doru Roiban, Rubén Agudo, Manfred T. Reetz, Stereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexene, Tetrahedron, Volume 69, Issue 26, 2013, Pages 5306-5311, ISSN 0040-4020, https://doi.org/10.1016/j.tet.2013.04.132.en_EN
dc.identifier.issn0040-4020-
dc.identifier.urihttp://hdl.handle.net/10637/15722-
dc.descriptionAcceso al contenido del artículo en la siguiente URL: https://doi.org/10.1016/j.tet.2013.04.132es_ES
dc.description.abstractThe selective partial oxidation of small non-functionalized molecules using biocatalysis based on P450 monooxygenases is known to be difficult due to the expected poor regio- and stereoselectivity, but in this study it was nevertheless attempted. 1-Methylcyclohexene was subjected to oxygen-mediated bio catalytic oxidation using P450-BM3 as the catalyst. Both oxidative hydroxylation and epoxidation were observed, in some cases leading to hydroxy epoxides with high diastereo- and enantioselectivity espe cially when employing BM3 mutants.en_EN
dc.language.isoen-
dc.publisherElsevier-
dc.relation.ispartofTetrahedron-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectEnantioselectivityen_EN
dc.subjectCH-activationen_EN
dc.subjectP450en_EN
dc.subjectMonooxygenaseen_EN
dc.subjectDiastereoselectivityen_EN
dc.titleStereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexeneen_EN
dc.typeArtículo-
dc.identifier.doi10.1016/j.tet.2013.04.132-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia


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