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http://hdl.handle.net/10637/15621
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DC Field | Value | Language |
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dc.contributor.other | Universidad San Pablo-CEU. Facultad de Medicina. | - |
dc.contributor.other | Grupo: Centro de metabolómica y bioanálisis (CEMBIO) | - |
dc.creator | Camunas-Alberca, Sandra M. | - |
dc.creator | Moran Garrido, María | - |
dc.creator | Sáiz Galindo, Jorge | - |
dc.creator | Villaseñor Solis, Alma Cristina | - |
dc.creator | Barbas Arribas, Coral. | - |
dc.date.accessioned | 2024-03-19T17:46:13Z | - |
dc.date.available | 2024-03-19T17:46:13Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.citation | Sandra M. Camunas-Alberca, Maria Moran-Garrido, Jorge Sáiz, Alma Villaseñor, Ameer Y. Taha, Coral Barbas, The role of oxylipins and their validation as biomarkers in the clinical context, TrAC Trends in Analytical Chemistry, Volume 164, 2023, 117065, ISSN 0165-9936, https://doi.org/10.1016/j.trac.2023.117065 | es_ES |
dc.identifier.issn | 1879-3142 | - |
dc.identifier.uri | http://hdl.handle.net/10637/15621 | - |
dc.description.abstract | Oxylipins are bioactive lipid mediators that participate in a wide range of processes, from blood flow to inflammation. In recent years, their exhaustive characterization as potential biomarkers has been actively pursued. However, several analytical challenges and sources of variability, like the low abundance of oxylipins in samples, their structural diversity, and the lack of harmonized and validated protocols for sample selection, collection, storage, and preparation have hampered their translation into clinical settings. In this review, these sources of variability are addressed and are exemplified with their application in recent clinical studies in different diseases. Our overall analysis highlights the need to achieve harmonized protocols for generating reliable and reproducible results that could be integrated into clinical practice to reach their full diagnostic and prognostic potential. | es_ES |
dc.description.sponsorship | Acuerdo Transformativo – 2023 | - |
dc.format | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | TrAC Trends in Analytical Chemistry | - |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
dc.rights | Open Access | - |
dc.subject | LC-MS/MS analysis | en_EN |
dc.subject | Oxygenated fatty acids | en_EN |
dc.subject | PUFAs | en_EN |
dc.subject | Eicosanoids | en_EN |
dc.subject | Prostaglandins | en_EN |
dc.subject | Leukotrienes | en_EN |
dc.subject | Pro-resolving lipid mediators | en_EN |
dc.subject | Bioactive lipid mediators | en_EN |
dc.title | The role of oxylipins and their validation as biomarkers in the clinical context | en_EN |
dc.type | Artículo | - |
dc.identifier.doi | 10.1016/j.trac.2023.117065 | - |
dc.relation.projectID | Ministry of Science and Innovation of Spain (MICINN) and the European Regional Development Fund FEDER, grant number PID2021-122490NB-I00 a | - |
dc.relation.projectID | La Caixa Foundation, grant number 01-09-2018-01-09-2020 | - |
dc.centro | Universidad San Pablo-CEU | - |
Appears in Collections: | Medicina |
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