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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Ciencias Farmacéuticas y de la Salud-
dc.creatorCoderch Boué, Claire-
dc.creatorArranz Herrero, Javier-
dc.creatorNistal Villán, Estanislao-
dc.creatorPascual-Teresa Fernández, Beatriz de-
dc.creatorRius Rocabert, Sergio-
dc.date.accessioned2024-03-01T17:11:17Z-
dc.date.available2024-03-01T17:11:17Z-
dc.date.issued2023-05-20-
dc.identifier.citationCoderch, C.; Arranz-Herrero, J.; Nistal-Villan, E.; de Pascual-Teresa, B.; Rius-Rocabert, S. The Many Ways to Deal with STING. Int. J. Mol. Sci. 2023, 24, 9032. https://doi.org/10.3390/ijms24109032es_ES
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10637/15530-
dc.description.abstractThe stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN- and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.es_ES
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.rightsOpen Access-
dc.subjectSTINGen_EN
dc.subjectIFNen_EN
dc.subjectAntiviral responseen_EN
dc.titleThe Many Ways to Deal with STINGen_EN
dc.typeArtículo-
dc.identifier.doi10.3390/ijms24109032-
dc.relation.projectIDMinisterio de Ciencia e Innovación PID2019-105761RBI00/ AEI/10.13039/501100011033-
dc.relation.projectIDJ.A-H. was supported by the PFIS fellowship co-funded by the FEDER/FSE and the ISCIII-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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