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RND3 potentiates proinflammatory activation through NOTCH signaling in activated macrophages


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Title: RND3 potentiates proinflammatory activation through NOTCH signaling in activated macrophages
Authors : Romero de Ávila, María José
López López, Susana
García Blázquez, Aarón
Ruiz García, Almudena
González Gómez, María Julia
Nueda, María Luisa
Baladrón, Victoriano
Pérez Roger, Ignacio
Poch Jiménez, Enric
Ballester Lurbe, Begoña
García Ramírez, José Javier
Monsalve, Eva M.
Díaz Guerra, María José M.
Keywords: MacrófagosMacrophagesSistema inmuneImmune systemInmunologíaImmunologyProteínaProteinsInflamaciónInflammationCélulaCells
Publisher: Hindawi
Citation: De Ávila, M.J.R., López-López, S., García-Blázquez, A., Ruiz-García, A., González-Gómez, M.J., Nueda, M.L., Baladrón, V., Pérez-Roger, I., Poch, E., Ballester-Lurbe, B., García-Ramírez, J.J., Monsalve, E.M. & Díaz-Guerra, M.J.M. (2024). RND3 potentiates proinflammatory activation through NOTCH signaling in activated macrophages. Journal of Immunology Research, vol. 2024, art. 2264799. DOI: https://doi.org/10.1155/2024/2264799
Abstract: Macrophage activation is a complex process with multiple control elements that ensures an adequate response to the aggressor pathogens and, on the other hand, avoids an excess of inflammatory activity that could cause tissue damage. In this study, we have identified RND3, a small GTP-binding protein, as a new element in the complex signaling process that leads to macrophage activation. We show that RND3 expression is transiently induced in macrophages activated through Toll receptors and potentiated by IFN-γ. We also demonstrate that RND3 increases NOTCH signaling in macrophages by favoring NOTCH1 expression and its nuclear activity; however, Rnd3 expression seems to be inhibited by NOTCH signaling, setting up a negative regulatory feedback loop. Moreover, increased RND3 protein levels seem to potentiate NFκB and STAT1 transcriptional activity resulting in increased expression of proinflammatory genes, such as Tnf-α, Irf-1, or Cxcl-10. Altogether, our results indicate that RND3 seems to be a new regulatory element which could control the activation of macrophages, able to fine tune the inflammatory response through NOTCH.
URI: http://hdl.handle.net/10637/15506
Rights : http://creativecommons.org/licenses/by/4.0/deed.es
Open Access
ISSN: 2314-8861
2314-7156 (Electrónico)
Issue Date: 2-Feb-2024
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Ciencias Biomédicas





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