Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15313

A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity

There are no files associated with this item.
no-thumbnail
Title: A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity
Authors : Sanchez-Carrillo, Sergio
Ciordia, Sergio
Rojo Blanco, David
Zubeldia Varela, Elisa
Méndez-García, Celia
Martínez-Martínez, Mónica
Barbas Arribas, Coral.
Ruiz-Ruiz, Susana
Moya, Andrés
Garriga, Marina
Salazar Sánchez, Nuria
Botella-Carretero, José I.
Vega-Piñero, Belén
Gonzalez de los Reyes-Gavilán, Clara
Campo, Rosa del
Ferrer, Manuel
Keywords: Body weight lossGut microbiotaBariatric surgeryObesity
Publisher: Elsevier
Citation: Sanchez-Carrillo, S., Ciordia, S., Rojo, D., Zubeldia-Varela, E., Méndez-García, C., Martínez-Martínez, M., Barbas, C., Ruiz-Ruiz, S., Moya, A., Garriga, M., Salazar, N., Botella-Carretero, J. I., Vega-Piñero, B., de Los Reyes-Gavilán, C. G., Del Campo, R., & Ferrer, M. (2021). A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity. Journal of pharmaceutical and biomedical analysis, 193, 113747. https://doi.org/10.1016/j.jpba.2020.113747
Abstract: Obesity has reached an epidemic level worldwide, and bariatric surgery (BS) has been proven to be the most efficient therapy to reduce severe obesity-related comorbidities. Given that the gut microbiota plays a causal role in obesity development and that surgery may alter the gut environment, investigating the impact of BS on the microbiota in the context of severe obesity is important. Although, alterations at the level of total gut bacteria, total gene content and total metabolite content have started to be disentangled, a clear deficit exists regarding the analysis of the active fraction of the microbiota, which is the fraction that is most reactive to the BS. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics and metabolomics in 40 severely obese volunteers. Samples from each volunteer were obtained under basal conditions, after a short high protein and calorie-restricted diet, and 1 and 3 months after BS, including laparoscopic surgery through Roux-en-Y Gastric Bypass or Sleeve Gastrectomy. The results revealed for the first time the most active microbes and metabolic flux distribution pre- and post-surgery and deciphered main differences in the way sugars and short-fatty acids are metabolized, demonstrating that less energy-generating and anaerobic metabolism and detoxification mechanisms are promoted post-surgery. A comparison with non-obese proteome data further signified different ways to metabolize sugars and produce short chain fatty acids and deficiencies in proteins involved in iron transport and metabolism in severely obese individuals compared to lean individuals.
Description: Acceso al texto completo del artículo, disponible desde el sitio de la revista usando DOI: https://doi.org/10.1016/j.jpba.2020.113747
URI: http://hdl.handle.net/10637/15313
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN: 1873-264X
Issue Date: 30-Jan-2021
Center : Universidad San Pablo-CEU
Appears in Collections:Medicina





Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.