Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/14775

Functionalization of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain


Vista previa

Ver/Abrir:
 functionalization_montejo-2022.pdf
2,8 MB
Adobe PDF
Título : Functionalization of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain
Autor : Alonso González, Mario
Barcia, Emilia
González, Juan Francisco
Montejo Rubio, María Consuelo
García García, Luis
Villa Hermosilla, Mónica Carolina
Negro, Sofía
Fraguas Sánchez, Ana Isabel
Fernández Carballido, Ana
Materias: Alzheimer’s diseaseMorin hydratePLGANanoparticlesBlood–brain barrierRhodamine B
Editorial : MDPI
Citación : Alonso, M.; Barcia, E.; González, J.-F.; Montejo, C.; García-García, L.; Villa-Hermosilla, M.-C.; Negro, S.; Fraguas-Sánchez, A.-I.; Fernández-Carballido, A. Functionalization of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain. Pharmaceutics 2022, 14, 2348. https://doi.org/10.3390/ pharmaceutics14112348
Resumen : Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, with its incidence constantly increasing. To date, there is no cure for the disease, with a need for new and effective treatments. Morin hydrate (MH) is a naturally occurring flavonoid of the Moraceae family with antioxidant and anti-inflammatory properties; however, the blood–brain barrier (BBB) prevents this flavonoid from reaching the CNS when aiming to potentially treat AD. Seeking to use the LAT-1 transporter present in the BBB, a nanoparticle (NPs) formulation loaded with MH and functionalized with phenylalanine-phenylalanine dipeptide was developed (NPphe-MH) and compared to non-functionalized NPs (NP-MH). In addition, two formulations were prepared using rhodamine B (Rh-B) as a fluorescent dye (NPphe-Rh and NP-Rh) to study their biodistribution and ability to cross the BBB. Functionalization of PLGA NPs resulted in high encapsulation efficiencies for both MH and Rh-B. Studies conducted in Wistar rats showed that the presence of phenylalanine dipeptide in the NPs modified their biodistribution profiles, making them more attractive for both liver and lungs, whereas non-functionalized NPs were predominantly distributed to the spleen. Formulation NPphe-Rh remained in the brain for at least 2 h after administration.
URI : http://hdl.handle.net/10637/14775
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
OpenAccess
ISSN : 1999-4923
Fecha de publicación : 31-oct-2022
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.