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Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

Title: Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
metadata.dc.creator: Gil Ortega, Marta.
García Prieto, Concepción F.
Ruíz Gayo, Mariano.
Somoza Hernández, Beatriz.
Keywords: Blood vesselsVasculatureNoradrenaline
Publisher: Hindawi
Citation: Fernández-Alfonso MS, Gil-Ortega M, García-Prieto CF, Aranguez I, Ruiz-Gayo M, Somoza B. Mechanisms of perivascular adipose tissue dysfunction in obesity. Int J Endocrinol. 2013;2013:402053. doi: 10.1155/2013/402053
Abstract: Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function. However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease.The aim of this review is to focus on PVAT dysfunction mechanisms in obesity
Description: En colaboración con: Maria S. Fernández-Alfonso e Isabel Aranguez
Rights :
ISSN: 1687-8345
Issue Date: 7-Nov-2013
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia

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