Fasciolosis : recent update in vaccines development and their efficacy

Abstract

Fasciolosis is caused by F. hepatica and F. gigantica. It is of economic and zoonotic importance. Several strategies for control of fasciolosis are being used; these include vaccination of animals that are at risk and control of the snails that carry the parasite. Several types of vaccines, such as recombinant cathepsin, mixed recombinant vaccine, fatty-acid-binding proteins, a cocktail of recombinant and fatty-acid-binding vaccines, nucleic acid-based vaccines and gene-silencing methods have been reported to show efficacy ranges of 32-75%, 52-79%, 8-36%, 43-68%, 74-100% and 90% respectively. These are currently undergoing experimental testing against fasciolosis. The study described in this paper was carried out to discover the comparative efficacy of these vaccines in the enhancement of the immune response in order to find the most effective method so that future research could focus on the development of that type of vaccine. Besides immunization, control of the intermediate host of the parasite (snail) is also an effective way to control fasciolosis. Snails are controlled through the use of physical, chemical and biological methods. The most effective of these is biological control using Sphaerodema urinator as a predator of snails.