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Subclinical hypothyroidism in advanced chronic kidney disease patients: prevalence and associated factors


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Título : Subclinical hypothyroidism in advanced chronic kidney disease patients: prevalence and associated factors
Autor : Reque Santiváñez, Javier
García Peris, Beatriz
Panizo González, Nayara
Pérez Alba, Alejandro
D'Marco Gascón, Luis Gerardo
Collado Boira, Eladio Joaquín
Materias: Diabetic nephropaties.Albuminuria.Hypothyroidism.Hipotiroidismo.Diabetes - Complicaciones y secuelas.
Editorial : Hindawi
Citación : Reque Santivañez, J., Garcia Peris, B., Panizo Gonzalez, N., Perez Alba, A., D'Marco, L. & Collado Boira, E. (2022). Subclinical hypothyroidism in advanced chronic kidney disease patients: prevalence and associated factors. Journal of Thyroid Research, vol. 2022, art. 1077553 (17 may.). DOI: https://doi.org/10.1155/2022/1077553
Resumen : Introduction. Renal function and thyroid metabolism are tightly related. However, evidence about subclinical hypothyroidism prevalence in patients with chronic kidney disease and its related factors is scarce. Objectives. Our aim is to analyze subclinical hypothyroidism prevalence and its related factors in patients with advanced chronic kidney disease. Materials and methods. Nondialysis-dependent patients with chronic kidney disease at stages 3 to 5 were included. Other inclusion criteria were age above 18 years and clinical stability. Patients with diagnosed thyroid illnesses were excluded. Subclinical hypothyroidism was de ned as thyroid stimulating hormone (TSH) > 5.3 mU/L, with free thyroxine 4 (FT4) between 0.54 and 1.24 ng/dl. Filiation data, comorbidities, and routine blood and urine test results were registered. Results. A total of 299 patients were included. Of them, 184 (61.5%) were men. The mean age was 71 ± 13 years old. The mean glomerular fltration rate (CKD-EPI) was 22 ± 9 ml/min/ 1.73m2. According to chronic kidney disease stages, global distribution of patients was as follows: Stage 3, 67 patients (22.4%); Stage 4, 155 patients (51.8%); and Stage 5, 77 patients (25.8%). We found subclinical hypothyroidism in 54 (18.1%) patients. According to chronic kidney disease stages, distribution of affected patients was as follows: Stage 3, 9 patients (13%); Stage 4, 25 patients (16.1%); and Stage 5, 20 patients (26%). Di¤erences among stages were statistically signifcant. By univariate analysis, factors related with subclinical hypothyroidism were as follows: age RR 1.048 (95% CI 1.019–1.078; p = 0.001), hypertension RR 2.705 (95% CI 1.026–7.130; p = 0.04), glomerular fltration rate RR 0.962 (95% CI 0.929–0.996; p = 0.03), and proteinuria higher than 1 gram/day RR 2.387 (95% CI 1.303–4.374; p = 0.005). By multivariate analysis adjusted by age, hypertension, glomerular fltration rate, proteinuria, diabetes, and cardiovascular disease history, only age RR 1.016 (95% CI 1.009–1.028; p = 0.04) and glomerular fltration rate RR 0.963 (95% CI 0.930–0.997; p = 0.03) preserved their independent association with subclinical hypothyroidism. Conclusions. Subclinical hypothyroidism prevalence in patients with chronic kidney disease is high and increases with renal disease severity. Factors independently related to subclinical hypothyroidism are age and glomerular fltration rate.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://downloads.hindawi.com/journals/jtr/2022/1077553.pdf
URI : http://hdl.handle.net/10637/14389
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2090-8067
2042-0072 (Electrónico)
Idioma: es
Fecha de publicación : 17-may-2022
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía





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