Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/14277

Intra-osseous infiltration of adipose mesenchymal stromal cells and plasma rich in growth factors to treat acute full depth cartilage defects in a rabbit model serum osteoarthritis biomarkers and macroscopical assessment


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Title: Intra-osseous infiltration of adipose mesenchymal stromal cells and plasma rich in growth factors to treat acute full depth cartilage defects in a rabbit model serum osteoarthritis biomarkers and macroscopical assessment
Authors : Torres Torrillas, Marta
Damiá Giménez, Elena
Peláez Gorrea, Pau
Miguel Pastor, Laura
Cuervo Serrato, Belén
Cerón, José J.
Carrillo Poveda, José María.
Rubio Zaragoza, Mónica.
Sopena Juncosa, Joaquín Jesús.
Keywords: Cartílagos - Regeneración.Cartilage - Regeneration.Osteoartritis - Tratamiento.Osteoarthritis - Treatment.Infiltraciones terapéuticas.Infiltrations - Therapeutic use.Plaquetas.Biochemical markers.Crecimiento - Factores.Plasma sanguíneo.Blood plasma.Growth factors.Blood platelets.Marcadores bioquímicos.
Publisher: Frontiers Media
Citation: Torres-Torrillas, M., Damiá, E., Peláez, P., Miguel-Pastor, L., Cuervo, B., Cerón, J. J., Carrillo, J. M., Rubio, M. & Sopena, J. J. (2022). Intra-osseous infiltration of adipose mesenchymal stromal cells and plasma rich in growth factors to treat acute full depth cartilage defects in a rabbit model: Serum osteoarthritis biomarkers and macroscopical assessment. Frontiers in Veterinary Science, vol. 9, art. 1057079 (20 dec.). DOI: https://doi.org/10.3389/fvets.2022.1057079
Abstract: Introduction: Intra-articular infiltration of plasma rich in growth factors (PRGF) and adipose mesenchymal stromal cells (AMSCs) are known to inhibit osteoarthritis progression. However, in severely a􀀀ected patients, the treatment cannot reach the deeper layers of the articular cartilage; thus, its potential is limited. To overcome this limitation, intra-osseous infiltrations have been suggested. The purpose of this study is to assess the impact of intra- osseous infiltration therapies on serum biomarkers of osteoarthritis and to assess cartilage regeneration macroscopically. Materials and methods: A total of 80 rabbits were divided into four groups based on the intra-osseous treatment administered on the day of surgery: control, PRGF, AMSCs and a combination of PRGF + AMSCs. In addition, all groups received a single intra-articular administration of PRGF on the same day. Serum biomarker levels were measured before infiltration and 28-, 56-, and 84-days post infiltration, and macroscopical assessment was conducted at 56- and 84-days follow-up post infiltration. Results: In the PRGF + AMSCs group, significantly lower concentrations of hyaluronic acid and type II collagen cleavage neoepitope were recorded at all time points during the study, followed by PRGF, AMSCs and control groups. Regarding macroscopical assessment, lower scores were obtained in PRGF + AMSCs group at all study times. Discussion: The results suggest that the combination of intra-articular PRGF with intra-osseous PRGF or AMSCs achieves better results in rabbits with acute chondral defects and that intra-osseous infiltration is a safe procedure.
Description: Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.frontiersin.org/articles/10.3389/fvets.2022.1057079/full
URI: http://hdl.handle.net/10637/14277
Rights : http://creativecommons.org/licenses/by/4.0/deed.es
ISSN: 2297-1769 (Electrónico)
Issue Date: 20-Dec-2022
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Medicina y Cirugía Animal





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