Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/14190

Biomarkers and "de novo" protein design can improve precise amino acid nutrition in broilers


Thumbnail

See/Open:
 Biomarkers_Cambra_ANIMALS_2022.pdf
14,02 MB
Adobe PDF
Title: Biomarkers and "de novo" protein design can improve precise amino acid nutrition in broilers
Authors : Cambra López, María
Marín García, Pablo Jesús
Lledó Morell, Clara
Cerisuelo García, Alba
Pascual Amorós, Juan José
Keywords: Proteínas.Proteins.Poultry - Feeding and feeds - Biochemical aspects.Amino acids.Aves de corral - Alimentación - Aspectos bioquímicos.Aminoácidos.
Publisher: MDPI
Citation: Cambra-López, M., Marín-García, P. J., Lledó, C., Cerisuelo, A. & Pascual, J. J. (2022). Biomarkers and "de novo" protein design can improve precise amino acid nutrition in broilers. Animals, vol. 12, i. 7 (06 apr.), art. 935. DOI: https://doi.org/10.3390/ani12070935
Abstract: Precision nutrition in broilers requires tools capable of identifying amino acid imbalances individually or in groups, as well as knowledge on how more digestible proteins can be designed for innovative feeding programs adjusted to animals’ dynamic requirements. This work proposes two potential tools, combining traditional nutrition with biotechnological, metabolomic, computational and protein engineering knowledge, which can contribute to improving the precise amino acid nutrition of broilers in the future: (i) the use of serum uric nitrogen content as a rapid biomarker of amino acid imbalances, and (ii) the design and modeling of de novo proteins that are fully digestible and fit exactly to the animal’s requirements. Each application is illustrated with a case study. Case study 1 demonstrates that serum uric nitrogen can be a useful rapid indicator of individual or group amino acid deficiencies or imbalances when reducing dietary protein and adjusting the valine and arginine to lysine ratios in broilers. Case study 2 describes a stepwise approach to design an ideal protein, resulting in a potential amino acid sequence and structure prototype that is ideally adjusted to the requirements of the targeted animal, and is theoretically completely digestible. Both tools can open up new opportunities to form an integrated framework for precise amino acid nutrition in broilers, helping us to achieve more efficient, resilient, and sustainable production. This information can help to determine the exact ratio of amino acids that will improve the efficiency of the use of nitrogen by poultry.
Description: Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-2615/12/7/935
Este artículo pertenece al número especial "Precision Poultry Farming".
URI: http://hdl.handle.net/10637/14190
Rights : http://creativecommons.org/licenses/by/4.0/deed.es
ISSN: 2076-2615 (Electrónico)
Language: es
Issue Date: 6-Apr-2022
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos





Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.