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Immunophenotypic differences in tumor-infiltrating lymphocytes and neovascularization between primary cutaneous melanoma with and without metastasis : an immunohistochemical study of 80 cases

Título : Immunophenotypic differences in tumor-infiltrating lymphocytes and neovascularization between primary cutaneous melanoma with and without metastasis : an immunohistochemical study of 80 cases
Autor : Salgüero Fernández, Irene
Roustán Gullón, Gastón
Requena Caballero, Luis
Suárez Massa, Dolores
García Fresnadillo, Diego
Redondo García, José Ignacio
Nájera Botello, Laura
Materias: Linfocitos - Uso terapéutico.Metastasis.Infiltraciones terapéuticas.Melanoma.Metástasis.Lymphocytes - Therapeutic use.Piel - Tumores - Tratamiento.Skin - Tumors - Treatment.Infiltrations - Therapeutic use.
Editorial : Wolters Kluwer
Citación : Salgüero, I., Roustán, G., Requena, L., Suárez, D., García-Fresnadillo, D., Redondo, J. I. & Nájera, L. (2021). Immunophenotypic differences in tumor-infiltrating lymphocytes and neovascularization between primary cutaneous melanoma with and without metastasis: an immunohistochemical study of 80 cases. The American Journal of Dermatopathology, vol. 43, i. 11 (nov.), pp. 811–818. DOI: https://doi.org/10.1097/DAD.0000000000001907
Resumen : The prognostic implications of the immunophenotype of the tumor-infiltrating lymphocytes in primary cutaneous melanoma are well known. In recent years, the study of this immunophenotype has also resulted in immunotherapeutic consequences. The aims of this study were to characterize the subpopulations of tumor-infiltrating lymphocytes in primary cutaneous melanoma, in cases with and without metastasis, as well as the neovascularization associated with the primary neoplasm, and its influence on the development of metastasis. To this end, the immunophenotype of tumorinfiltrating lymphocytes and the neovascularization of 80 patients with primary cutaneous melanoma (40 each with metastatic and non-metastatic melanoma) were analyzed by immunohistochemistry for CD3, CD4, CD8, FOXP3, PD-1, CD31, and D2- 40 antibodies. We found that higher frequencies of tumor-infiltrating lymphocytes with brisk pattern, and CD4+, CD8+, and CD20+ cells in tumor-infiltrating lymphocytes, and a lower frequency of CD31+ vessels were histopathological features associated with better prognosis in primary cutaneous melanoma. Our results support the notion that immunohistochemical study of tumor-infiltrating lymphocytes and neovascularization in primary cutaneous melanoma may be helpful tools for identifying patients at increased risk of metastasis development.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://journals.lww.com/amjdermatopathology/Fulltext/2021/11000/Immunophenotypic_Differences_in_Tumor_Infiltrating.8.aspx
Este es el pre-print del siguiente artículo: Salgüero, I., Roustán, G., Requena, L., Suárez, D., García-Fresnadillo, D., Redondo, J. I., & Nájera, L. (2021). Immunophenotypic differences in tumor-infiltrating lymphocytes and neovascularization between primary cutaneous melanoma with and without metastasis: an immunohistochemical study of 80 cases. The American Journal of dermatopathology, 43(11), 811?818, que se ha publicado de forma definitiva en https://doi.org/10.1097/DAD.0000000000001907.
This is the pre-peer reviewed version of the following article: Salgüero, I., Roustán, G., Requena, L., Suárez, D., García-Fresnadillo, D., Redondo, J. I., & Nájera, L. (2021). Immunophenotypic differences in tumor-infiltrating lymphocytes and neovascularization between primary cutaneous melanoma with and without metastasis: an immunohistochemical study of 80 cases. The American Journal of dermatopathology, 43(11), 811?818, which has been published in final form at https://doi.org/10.1097/DAD.0000000000001907.
URI : http://hdl.handle.net/10637/13913
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0193-1091
1533-0311 (Electrónico)
Fecha de publicación : 23-nov-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal





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