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Staphylococcal phages and pathogenicity islands drive plasmid evolution


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Título : Staphylococcal phages and pathogenicity islands drive plasmid evolution
Autor : Humphrey, Suzanne
Millán, Álvaro Sán
Toll Riera, Macarena
Connolly, John
Flor Duro, Alejandra
Chen, John
Úbeda Morant, Carles
MacLean, R. Craig
Penadés Casanova, José Rafael
Materias: Bacterias patógenas.Pathogenic bacteria.Bacterial genetic.Evolutionary genetics.Bacteriophages.Genética bacteriana.Genética evolutiva.Bacteriófagos.
Editorial : Springer Nature
Citación : Humphrey, S., San Millán, Á., Toll-Riera, M., Connolly, J., Flor-Duro, A., Chen, J., Ubeda, C., MacLean, R.C., & Penadés, J.R. (2021). Staphylococcal phages and pathogenicity islands drive plasmid evolution. Nature Communications, vol. 12, art. 5845 (06 oct.). DOI: https://doi.org/10.1038/s41467-021-26101-5
Resumen : Conjugation has classically been considered the main mechanism driving plasmid transfer in nature. Yet bacteria frequently carry so-called non-transmissible plasmids, raising questions about how these plasmids spread. Interestingly, the size of many mobilisable and nontransmissible plasmids coincides with the average size of phages (~40 kb) or that of a family of pathogenicity islands, the phage-inducible chromosomal islands (PICIs, ~11 kb). Here, we show that phages and PICIs from Staphylococcus aureus can mediate intra- and inter-species plasmid transfer via generalised transduction, potentially contributing to non-transmissible plasmid spread in nature. Further, staphylococcal PICIs enhance plasmid packaging efficiency, and phages and PICIs exert selective pressures on plasmids via the physical capacity of their capsids, explaining the bimodal size distribution observed for non-conjugative plasmids. Our results highlight that transducing agents (phages, PICIs) have important roles in bacterial plasmid evolution and, potentially, in antimicrobial resistance transmission.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41467-021-26101-5.pdf
URI : http://hdl.handle.net/10637/13679
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2041-1723 (Electrónico)
Fecha de publicación : 6-oct-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Ciencias Biomédicas





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