Please use this identifier to cite or link to this item:
http://hdl.handle.net/10637/12998A role for Taok2 in "Listeria monocytogenes" vacuolar escape
| Title: | A role for Taok2 in "Listeria monocytogenes" vacuolar escape |
| Authors : | Quereda Torres, Juan José Morel, Camille López Montero, Noelia Ziveri, Jason Rolland, Steven Grenier, Théodore |
| Keywords: | Pathogenic bacteria.; Listeriosis.; Bacterias patógenas.; Cytoplasm.; Epithelial cells.; Citoplasma.; Células epiteliales. |
| Publisher: | Oxford University. |
| Citation: | Quereda, J.J., Morel, C., Lopez-Montero, N., Ziveri, J., Rolland, S., Grenier, T. et al. (2022). A role for Taok2 in "Listeria monocytogenes" vacuolar escape. The Journal of Infectious Diseases, vol. 225, i. 6 (15 mar.), pp. 1005–1010. DOI: https://doi.org/10.1093/infdis/jiaa367 |
| Abstract: | The bacterial pathogen Listeria monocytogenes invades host cells, ruptures the internalization vacuole, and reaches the cytosol for replication. A high-content small interfering RNA (siRNA) microscopy screen allowed us to identify epithelial cell factors involved in L. monocytogenes vacuolar rupture, including the serine/threonine kinase Taok2. Kinase activity inhibition using a specific drug validated a role for Taok2 in favoring L. monocytogenes cytoplasmic access. Furthermore, we showed that Taok2 recruitment to L. monocytogenes vacuoles requires the presence of pore-forming toxin listeriolysin O. Overall, our study identified the first set of host factors modulating L. monocytogenes vacuolar rupture and cytoplasmic access in epithelial cells. |
| Description: | Este artículo se encuentra disponible en la siguiente URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa367/5862450 En esta investigación también participan: Nathalie Aulner, Anne Danckaert, Alain Charbit, Jost Enninga, Pascale Cossart y Javier Pizarro Cerdá. |
| URI: | http://hdl.handle.net/10637/12998 |
| Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| ISSN: | 0022-1899. 1537-6613 (Electrónico). |
| Issue Date: | 15-Mar-2022 |
| Center : | Universidad Cardenal Herrera-CEU |
| Appears in Collections: | Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.