Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12943
Título : Maternal fructose intake increases liver H2S synthesis but exarcebates its fructose-induced decrease in female progeny.
Autor : Rodríguez, Lourdes.
Bocos de Prada, Carlos.
Rodrígo, Silvia.
Fauste Alonso, Elena.
Panadero Antón, María Isabel.
Materias: FructoseFetal programmingH2SLiverOxidative stress
Fecha de publicación : 10-ago-2020
Resumen : Scope : Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well-known risk factor for cardiovascular diseases while hydrogen sulfide (H2S), a product of its metabolism, has been proved to exert opposite effects to Hcy. Methods and results : First, we investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H2S synthesis of the progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% wt/vol) throughout gestation. Adult female descendants from fructosefed, control or glucose-fed mothers were studied. Females from fructose-fed mothers had elevated homocysteinemia, hepatic H2S production, cystathionine -lyase (CSE) (the key enzyme in H2S synthesis) expression and plasma H2S, versus the other two groups. Second, we studied how adult female progeny from control (C/F), fructose- (F/F) and glucose-fed (G/F) mothers responded to liquid fructose and compared them to the control group (C/C). Interestingly, both hepatic CSE expression and H2S synthesis were diminished by fructose intake, this effect being more pronounced in F/F females. Conclusions : Maternal fructose intake produces a fetal programming that increases hepatic H2S production and, in contrast, exacerbates its fructose-induced drop in female progeny.
Descripción : Artículo en colaboración: Silvia Rodrigo, Rodrigo Aguirre, Cristina Donis, Lourdes Rodríguez, Juan J. Álvarez-Millán1, María I. Panadero, Paola Otero and Carlos Bocos
En: Molecular Nutrition Food Research. 2020. vol. 64 : 2000628. e-ISSN 1613-4133
URI : http://hdl.handle.net/10637/12943
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000723166
Aparece en las colecciones: Facultad de Farmacia

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