Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12940
Título : Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny.
Autor : Rodríguez, Lourdes.
Bocos de Prada, Carlos.
Panadero Antón, María Isabel.
Rodrígo, Silvia.
Materias: FructosePregnancyFetal programmingEpigeneticsCholesterol
Fecha de publicación : 10-ago-2018
Resumen : Fructose consumption from added sugars correlates with the epidemic rise in obesity, metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. We have investigated whether maternal fructose intake produces subsequent changes in cholesterol metabolism of progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% w/v solution) throughout gestation. Adult male and female descendants from fructose-fed, control or glucose-fed mothers were studied. Male offspring from fructose-fed mothers had elevated plasma HDL-cholesterol levels, whereas female progeny from fructose-fed mothers presented lower levels of non-HDL cholesterol versus the other two groups. Liver X-receptor (LXR), an important regulator of cholesterol metabolism, and its target genes such as scavenger receptor B1, ATP-binding cassette (ABC)G5 and cholesterol 7-alpha hydroxylase showed decreased gene expression in males from fructose-fed mothers and the opposite in the female progeny. Moreover, the expression of a number of LXR target genes related to lipogenesis paralleled to that for LXR expression. In accordance with this, LXR gene promoter methylation was increased in males from fructose-fed mothers and decreased in the corresponding group of females. Surprisingly, plasma folic acid levels, an important methyl-group donor, were augmented in males from fructose-fed mothers and diminished in female offspring. Maternal fructose intake produces a fetal programming that influences, in a gender-dependent manner, the transcription factor LXR epigenetically, and both hepatic mRNA gene expression and plasma parameters of cholesterol metabolism in adult progeny. Changes in the LXR promoter methylation might be related to the availability of the methyl donor folate.
Descripción : Artículo en colaboración: Elena Fauste, Maite de la Cuesta, Lourdes Rodríguez, Juan J. Álvarez-Millán1, María I. Panadero, Paola Otero, and Carlos Bocos.
En: Journal of Nutritional Biochemistry. 2018. vol. 61 : 163-172 p. e-ISSN 1873-4847
URI : http://hdl.handle.net/10637/12940
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000723163
Aparece en las colecciones: Facultad de Farmacia

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